Explore VTN/Vitronectin gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene functions in part as an adhesive glycoprotein. Differential expression of this protein can promote either cell adhesion or migration as it links cells to the extracellular matrix through a variety of ligands. These ligands include integrins, plasminogen activator inhibitor-1, and urokinase plasminogen activator receptor. This secreted protein can be present in the plasma as a monomer or dimer and forms a multimer in the extracellular matrix of several tissues. This protein also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors. This protein can also promote extracellular matrix degradation and thus plays a role in tumorigenesis. It is involved in a variety of other biological processes such as the regulation of the coagulation pathway, wound healing, and tissue remodeling. The heparin-binding domain of this protein give it anti-microbial properties. It is also a lipid binding protein that forms a principal component of high density lipoprotein. [provided by RefSeq, Aug 2020]
| Target ID |
GM-SE0548
|
| Target Name |
VTN/Vitronectin
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
7448
|
| Gene ID |
100059034 (Equus caballus), 101100765 (Felis catus), 22370 (Mus musculus), 29169 (Rattus norvegicus) 480621 (Canis lupus familiaris), 507525 (Bos taurus), 708499 (Macaca mulatta), 7448 (Homo sapiens)
|
| Target Alternative Names |
Aa1018,S-protein,Serum-spreading factor,V75,VN,VNT,VTN,Vitronectin,Vn,Vtn
|
| Uniprot Accession |
P29788,P04004
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Disease from KEGG |
PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Complement and coagulation cascades, Human papillomavirus infection, Proteoglycans in cancer
|
| Gene Ensembl |
ENSECAG00000015904, ENSMUSG00000017344, ENSCAFG00845007195, ENSBTAG00000016151, ENSMMUG00000019148, ENSG00000109072
|
Pre-made viral vector of VTN/Vitronectin cDNA Clones/ORF Plasmid
VTN/Vitronectin siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7448 | Pre-made Human VTN/VN/V75 siRNA oligo Duplex | 7448 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29169 | Pre-made Rat Vtn/Vn/Aa1018 siRNA oligo Duplex | 29169 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22370 | Pre-made Mouse Vtn/Vn siRNA oligo Duplex | 22370 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo708499 | Pre-made Cynomolgus/Rhesus macaque VTN siRNA oligo Duplex | 708499 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100765 | Pre-made Cat/Feline VTN siRNA oligo Duplex | 101100765 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo480621 | Pre-made Dog/Canine VTN siRNA oligo Duplex | 480621 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo507525 | Pre-made Bovines/Cattle VTN siRNA oligo Duplex | 507525 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100059034 | Pre-made Equine/Horse VTN siRNA oligo Duplex | 100059034 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
VTN/Vitronectin antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE0548-Ab | Human | Anti-Human VTN/Vitronectin monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-SE0548-Ab | Rat | Anti-Rat VTN/Vitronectin monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-SE0548-Ab | Mouse | Anti-Mouse VTN/Vitronectin monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-SE0548-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque VTN/Vitronectin monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-SE0548-Ab | Cat/Feline | Anti-Cat/Feline VTN/Vitronectin monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-SE0548-Ab | Dog/Canine | Anti-Dog/Canine VTN/Vitronectin monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-SE0548-Ab | Bovines/Cattle | Anti-Bovines/Cattle VTN/Vitronectin monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-SE0548-Ab | Equine/Horse | Anti-Equine/Horse VTN/Vitronectin monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
VTN/Vitronectin recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE0548-Ag | Human | Human VTN/Vitronectin recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-SE0548-Ag | Rat | Rat VTN/Vitronectin recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-SE0548-Ag | Mouse | Mouse VTN/Vitronectin recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-SE0548-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque VTN/Vitronectin recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-SE0548-Ag | Cat/Feline | Cat/Feline VTN/Vitronectin recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-SE0548-Ag | Dog/Canine | Dog/Canine VTN/Vitronectin recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-SE0548-Ag | Bovines/Cattle | Bovines/Cattle VTN/Vitronectin recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-SE0548-Ag | Equine/Horse | Equine/Horse VTN/Vitronectin recombinant protein | Mammalian cell | Detail |