Explore SFTPC gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010]
| Target ID |
GM-SE0471
|
| Target Name |
SFTPC
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
6440
|
| Gene ID |
100053773 (Equus caballus), 101089602 (Felis catus), 20389 (Mus musculus), 282071 (Bos taurus) 477385 (Canis lupus familiaris), 50683 (Rattus norvegicus), 6440 (Homo sapiens), 707696 (Macaca mulatta)
|
| Target Alternative Names |
BRICD6,Bricd6,PSP-C,Pulmonary surfactant-associated protein C,Pulmonary surfactant-associated proteolipid SPL(Val),SFTP2,SFTPC,SMDP2,SP-C,SP5,SPC,Sftp-2,Sftp2,Sftpc,Surfactant protein C,pro-SpC
|
| Uniprot Accession |
P21841,P15783,P22397,P11685,P11686,P55152
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Disease |
Lung Cancer
|
| Gene Ensembl |
ENSMUSG00000022097, ENSBTAG00000012560, ENSCAFG00845025534, ENSG00000168484, ENSMMUG00000013029
|
Pre-made viral vector of SFTPC cDNA Clones/ORF Plasmid
SFTPC siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6440 | Pre-made Human SFTPC/SP5/SP-C siRNA oligo Duplex | 6440 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo50683 | Pre-made Rat Sftpc/SP-C siRNA oligo Duplex | 50683 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20389 | Pre-made Mouse Sftpc/SP5/SPC siRNA oligo Duplex | 20389 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo707696 | Pre-made Cynomolgus/Rhesus macaque SFTPC/SP-C siRNA oligo Duplex | 707696 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101089602 | Pre-made Cat/Feline SFTPC siRNA oligo Duplex | 101089602 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477385 | Pre-made Dog/Canine SFTPC/SP-C/SFTP2 siRNA oligo Duplex | 477385 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282071 | Pre-made Bovines/Cattle SFTPC siRNA oligo Duplex | 282071 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100053773 | Pre-made Equine/Horse SFTPC siRNA oligo Duplex | 100053773 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SFTPC antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE0471-Ab | Human | Anti-Human SFTPC monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-SE0471-Ab | Rat | Anti-Rat SFTPC monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-SE0471-Ab | Mouse | Anti-Mouse SFTPC monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-SE0471-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SFTPC monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-SE0471-Ab | Cat/Feline | Anti-Cat/Feline SFTPC monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-SE0471-Ab | Dog/Canine | Anti-Dog/Canine SFTPC monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-SE0471-Ab | Bovines/Cattle | Anti-Bovines/Cattle SFTPC monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-SE0471-Ab | Equine/Horse | Anti-Equine/Horse SFTPC monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
SFTPC recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE0471-Ag | Human | Human SFTPC recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-SE0471-Ag | Rat | Rat SFTPC recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-SE0471-Ag | Mouse | Mouse SFTPC recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-SE0471-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SFTPC recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-SE0471-Ag | Cat/Feline | Cat/Feline SFTPC recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-SE0471-Ag | Dog/Canine | Dog/Canine SFTPC recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-SE0471-Ag | Bovines/Cattle | Bovines/Cattle SFTPC recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-SE0471-Ag | Equine/Horse | Equine/Horse SFTPC recombinant protein | Mammalian cell | Detail |