Explore CYP2E1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
Target ID |
GM-SE0139
|
Target Name |
CYP2E1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1571
|
Gene ID |
100066422 (Equus caballus), 13106 (Mus musculus), 1571 (Homo sapiens), 25086 (Rattus norvegicus) 282213 (Bos taurus), 415128 (Canis lupus familiaris), 554227 (Felis catus)
|
Target Alternative Names |
CYP2E1,Cyp2e1,Cyp2e,CYPIIE1,CPE1,CYP2E,P450-J,P450C2E,CYP2E2
|
Uniprot Accession |
Q05421,P05181,P05182,O18963,Q9MZY0
|
Uniprot Entry Name |
|
Protein Sub-location |
Secreted Protein/Potential Cytokines
|
Category |
|
Disease |
cancer
|
Disease from KEGG |
Metabolic pathways, Steroid hormone biosynthesis, Alcoholic liver disease, Chemical carcinogenesis - DNA adducts, Arachidonic acid metabolism, Linoleic acid metabolism, Drug metabolism - cytochrome P450
|
Gene Ensembl |
ENSECAG00000019088, ENSMUSG00000025479, ENSG00000130649, ENSCAFG00845027431
|
Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of CYP2E1 cDNA Clones/ORF Plasmid
CYP2E1 siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo1571 | Pre-made Human CYP2E1/CPE1/CYP2E siRNA oligo Duplex | 1571 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo25086 | Pre-made Rat Cyp2e1/Cyp2e siRNA oligo Duplex | 25086 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo13106 | Pre-made Mouse Cyp2e1/Cyp2e/CYPIIE1 siRNA oligo Duplex | 13106 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo554227 | Pre-made Cat/Feline CYP2E1/CYP2E2 siRNA oligo Duplex | 554227 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo415128 | Pre-made Dog/Canine CYP2E1 siRNA oligo Duplex | 415128 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo282213 | Pre-made Bovines/Cattle CYP2E1/CYPIIE1 siRNA oligo Duplex | 282213 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100066422 | Pre-made Equine/Horse CYP2E1 siRNA oligo Duplex | 100066422 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CYP2E1 antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-SE0139-Ab | Human | Anti-Human CYP2E1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
GM-Tg-rg-SE0139-Ab | Rat | Anti-Rat CYP2E1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
GM-Tg-mg-SE0139-Ab | Mouse | Anti-Mouse CYP2E1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
GM-Tg-felg-SE0139-Ab | Cat/Feline | Anti-Cat/Feline CYP2E1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
GM-Tg-cang-SE0139-Ab | Dog/Canine | Anti-Dog/Canine CYP2E1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
GM-Tg-bovg-SE0139-Ab | Bovines/Cattle | Anti-Bovines/Cattle CYP2E1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
GM-Tg-equg-SE0139-Ab | Equine/Horse | Anti-Equine/Horse CYP2E1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
CYP2E1 recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-SE0139-Ag | Human | Human CYP2E1 recombinant protein | Mammalian cell | Detail |
GM-Tg-rg-SE0139-Ag | Rat | Rat CYP2E1 recombinant protein | Mammalian cell | Detail |
GM-Tg-mg-SE0139-Ag | Mouse | Mouse CYP2E1 recombinant protein | Mammalian cell | Detail |
GM-Tg-felg-SE0139-Ag | Cat/Feline | Cat/Feline CYP2E1 recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-SE0139-Ag | Dog/Canine | Dog/Canine CYP2E1 recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-SE0139-Ag | Bovines/Cattle | Bovines/Cattle CYP2E1 recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-SE0139-Ag | Equine/Horse | Equine/Horse CYP2E1 recombinant protein | Mammalian cell | Detail |