Explore RASGRP1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP2286
|
| Target Name |
RASGRP1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
10125
|
| Gene ID |
100071578 (Equus caballus), 101093110 (Felis catus), 10125 (Homo sapiens), 19419 (Mus musculus)
29434 (Rattus norvegicus), 478255 (Canis lupus familiaris), 533125 (Bos taurus), 703838 (Macaca mulatta)
|
| Target Alternative Names |
CALDAG-GEFI,CALDAG-GEFII,CalDAG-GEFI,Calcium and DAG-regulated guanine nucleotide exchange factor II (CalDAG-GEFII),IMD64,RAS guanyl-releasing protein 1,RASGRP,RASGRP1,Ras guanyl-releasing protein,Rasgrp,Rasgrp1,calDAG-GEFII
|
| Uniprot Accession |
O95267,Q9Z1S3,Q9R1K8
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease from KEGG |
MAPK signaling pathway, Ras signaling pathway, Platelet activation, T cell receptor signaling pathway, Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer
|
| Gene Ensembl |
ENSECAG00000010114, ENSG00000172575, ENSMUSG00000027347, ENSCAFG00845026198, ENSBTAG00000021872, ENSMMUG00000018333
|
Pre-made viral vector of RASGRP1 cDNA Clones/ORF Plasmid
RASGRP1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10125 | Pre-made Human RASGRP1/IMD64/RASGRP siRNA oligo Duplex | 10125 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29434 | Pre-made Rat Rasgrp1/Rasgrp siRNA oligo Duplex | 29434 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19419 | Pre-made Mouse Rasgrp1/Rasgrp/calDAG-GEFII siRNA oligo Duplex | 19419 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703838 | Pre-made Cynomolgus/Rhesus macaque RASGRP1 siRNA oligo Duplex | 703838 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101093110 | Pre-made Cat/Feline RASGRP1 siRNA oligo Duplex | 101093110 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo478255 | Pre-made Dog/Canine RASGRP1/CalDAG-GEFI siRNA oligo Duplex | 478255 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo533125 | Pre-made Bovines/Cattle RASGRP1 siRNA oligo Duplex | 533125 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100071578 | Pre-made Equine/Horse RASGRP1 siRNA oligo Duplex | 100071578 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
RASGRP1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP2286-Ab | Human | Anti-Human RASGRP1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP2286-Ab | Rat | Anti-Rat RASGRP1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP2286-Ab | Mouse | Anti-Mouse RASGRP1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP2286-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque RASGRP1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP2286-Ab | Cat/Feline | Anti-Cat/Feline RASGRP1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP2286-Ab | Dog/Canine | Anti-Dog/Canine RASGRP1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP2286-Ab | Bovines/Cattle | Anti-Bovines/Cattle RASGRP1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP2286-Ab | Equine/Horse | Anti-Equine/Horse RASGRP1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
RASGRP1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP2286-Ag | Human | Human RASGRP1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP2286-Ag | Rat | Rat RASGRP1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP2286-Ag | Mouse | Mouse RASGRP1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP2286-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque RASGRP1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP2286-Ag | Cat/Feline | Cat/Feline RASGRP1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP2286-Ag | Dog/Canine | Dog/Canine RASGRP1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP2286-Ag | Bovines/Cattle | Bovines/Cattle RASGRP1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP2286-Ag | Equine/Horse | Equine/Horse RASGRP1 VLP (virus-like particle) | HEK293 | Products Developing |
