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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene may regulate the signaling activity of beta-catenin and is required to maintain transcription of genes that control intracellular calcium cycling including ryanodine receptor 2, ankyrin-B, triadin, and calcium channel, voltage-dependent, L type, alpha 1C. Mutations in this gene are associated with different inherited cardiac conditions including Arrythmogenic Cardiomyopathy, Brugada Syndrome, and Idiopathic Ventricular Fibrillation. A processed pseudogene with high similarity to this gene has been mapped to chromosome 12p13. [provided by RefSeq, May 2022]
| Target ID |
GM-MP2245
|
| Target Name |
Plakophilin 2/PKP2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5318
|
| Gene ID |
100070065 (Equus caballus), 100429378 (Macaca mulatta), 101091710 (Felis catus), 287925 (Rattus norvegicus)
486613 (Canis lupus familiaris), 5318 (Homo sapiens), 537784 (Bos taurus), 67451 (Mus musculus)
|
| Target Alternative Names |
1200008D14Rik,1200012P04Rik,ARVD9,PKP2,Pkp2,Pkp2l,Plakophilin 2,Plakophilin-2
|
| Uniprot Accession |
F1M7L9,Q99959,Q9CQ73
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease from KEGG |
Arrhythmogenic right ventricular cardiomyopathy
|
| Gene Ensembl |
ENSECAG00000013566, ENSMMUG00000000595, ENSCAFG00845016150, ENSG00000057294, ENSBTAG00000002651, ENSMUSG00000041957
|
Pre-made viral vector of Plakophilin 2/PKP2 cDNA Clones/ORF Plasmid
Plakophilin 2/PKP2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5318 | Pre-made Human PKP2/ARVD9 siRNA oligo Duplex | 5318 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo287925 | Pre-made Rat Pkp2 siRNA oligo Duplex | 287925 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo67451 | Pre-made Mouse Pkp2/Pkp2l/1200008D14Rik siRNA oligo Duplex | 67451 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100429378 | Pre-made Cynomolgus/Rhesus macaque PKP2 siRNA oligo Duplex | 100429378 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101091710 | Pre-made Cat/Feline PKP2 siRNA oligo Duplex | 101091710 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486613 | Pre-made Dog/Canine PKP2 siRNA oligo Duplex | 486613 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo537784 | Pre-made Bovines/Cattle PKP2 siRNA oligo Duplex | 537784 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100070065 | Pre-made Equine/Horse PKP2 siRNA oligo Duplex | 100070065 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Plakophilin 2/PKP2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP2245-Ab | Human | Anti-Human Plakophilin 2/PKP2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP2245-Ab | Rat | Anti-Rat Plakophilin 2/PKP2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP2245-Ab | Mouse | Anti-Mouse Plakophilin 2/PKP2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP2245-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Plakophilin 2/PKP2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP2245-Ab | Cat/Feline | Anti-Cat/Feline Plakophilin 2/PKP2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP2245-Ab | Dog/Canine | Anti-Dog/Canine Plakophilin 2/PKP2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP2245-Ab | Bovines/Cattle | Anti-Bovines/Cattle Plakophilin 2/PKP2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP2245-Ab | Equine/Horse | Anti-Equine/Horse Plakophilin 2/PKP2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
Plakophilin 2/PKP2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP2245-Ag | Human | Human Plakophilin 2/PKP2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP2245-Ag | Rat | Rat Plakophilin 2/PKP2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP2245-Ag | Mouse | Mouse Plakophilin 2/PKP2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP2245-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Plakophilin 2/PKP2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP2245-Ag | Cat/Feline | Cat/Feline Plakophilin 2/PKP2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP2245-Ag | Dog/Canine | Dog/Canine Plakophilin 2/PKP2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP2245-Ag | Bovines/Cattle | Bovines/Cattle Plakophilin 2/PKP2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP2245-Ag | Equine/Horse | Equine/Horse Plakophilin 2/PKP2 VLP (virus-like particle) | HEK293 | Products Developing |
