Explore DLK/MAP3K12 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
| Target ID |
GM-MP2193
|
| Target Name |
DLK/MAP3K12
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
7786
|
| Gene ID |
100064002 (Equus caballus), 101087164 (Felis catus), 25579 (Rattus norvegicus), 26404 (Mus musculus)
505427 (Bos taurus), 607170 (Canis lupus familiaris), 703059 (Macaca mulatta), 7786 (Homo sapiens)
|
| Target Alternative Names |
DLK,Dual leucine zipper bearing kinase (DLK),HP09298,Leucine-zipper protein kinase (ZPK),MAP3K12,MAPK-upstream kinase (MUK),MEKK12,MUK,Map3k12,Mitogen-activated protein kinase kinase kinase 12,Mixed lineage kinase,PK,ZPK,ZPKP1,Zpk
|
| Uniprot Accession |
Q63796,Q60700,Q12852
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease from KEGG |
MAPK signaling pathway
|
| Gene Ensembl |
ENSECAG00000010837, ENSMUSG00000023050, ENSBTAG00000020758, ENSCAFG00845019204, ENSMMUG00000006613, ENSG00000139625
|
DLK/MAP3K12 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7786 | Pre-made Human MAP3K12/DLK/MUK siRNA oligo Duplex | 7786 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25579 | Pre-made Rat Map3k12/PK/DLK siRNA oligo Duplex | 25579 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo26404 | Pre-made Mouse Map3k12/DLK/MUK siRNA oligo Duplex | 26404 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703059 | Pre-made Cynomolgus/Rhesus macaque MAP3K12 siRNA oligo Duplex | 703059 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101087164 | Pre-made Cat/Feline MAP3K12 siRNA oligo Duplex | 101087164 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo607170 | Pre-made Dog/Canine MAP3K12 siRNA oligo Duplex | 607170 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo505427 | Pre-made Bovines/Cattle MAP3K12 siRNA oligo Duplex | 505427 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064002 | Pre-made Equine/Horse MAP3K12 siRNA oligo Duplex | 100064002 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
DLK/MAP3K12 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP2193-Ab | Human | Anti-Human DLK/MAP3K12 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP2193-Ab | Rat | Anti-Rat DLK/MAP3K12 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP2193-Ab | Mouse | Anti-Mouse DLK/MAP3K12 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP2193-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque DLK/MAP3K12 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP2193-Ab | Cat/Feline | Anti-Cat/Feline DLK/MAP3K12 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP2193-Ab | Dog/Canine | Anti-Dog/Canine DLK/MAP3K12 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP2193-Ab | Bovines/Cattle | Anti-Bovines/Cattle DLK/MAP3K12 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP2193-Ab | Equine/Horse | Anti-Equine/Horse DLK/MAP3K12 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
DLK/MAP3K12 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP2193-Ag | Human | Human DLK/MAP3K12 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP2193-Ag | Rat | Rat DLK/MAP3K12 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP2193-Ag | Mouse | Mouse DLK/MAP3K12 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP2193-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque DLK/MAP3K12 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP2193-Ag | Cat/Feline | Cat/Feline DLK/MAP3K12 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP2193-Ag | Dog/Canine | Dog/Canine DLK/MAP3K12 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP2193-Ag | Bovines/Cattle | Bovines/Cattle DLK/MAP3K12 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP2193-Ag | Equine/Horse | Equine/Horse DLK/MAP3K12 VLP (virus-like particle) | HEK293 | Products Developing |
