Explore GAB2 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
| Target ID |
GM-MP2135
|
| Target Name |
GAB2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
9846
|
| Gene ID |
100062877 (Equus caballus), 101101410 (Felis catus), 14389 (Mus musculus), 485167 (Canis lupus familiaris)
529346 (Bos taurus), 700197 (Macaca mulatta), 84477 (Rattus norvegicus), 9846 (Homo sapiens)
|
| Target Alternative Names |
GAB2,Gab2,p97,D130058I17Rik
|
| Uniprot Accession |
Q9Z1S8,Q9EQH1,Q9UQC2
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
|
| Disease |
cancer
|
| Disease from KEGG |
Ras signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Osteoclast differentiation, Fc epsilon RI signaling pathway, Chronic myeloid leukemia
|
| Gene Ensembl |
ENSECAG00000020164, ENSMUSG00000004508, ENSCAFG00845007967, ENSBTAG00000002922, ENSMMUG00000017477, ENSG00000033327
|
| Target Classification |
|
Pre-made viral vector of GAB2 cDNA Clones/ORF Plasmid
GAB2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo9846 | Pre-made Human GAB2 siRNA oligo Duplex | 9846 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo84477 | Pre-made Rat Gab2 siRNA oligo Duplex | 84477 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14389 | Pre-made Mouse Gab2/p97/D130058I17Rik siRNA oligo Duplex | 14389 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo700197 | Pre-made Cynomolgus/Rhesus macaque GAB2 siRNA oligo Duplex | 700197 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101101410 | Pre-made Cat/Feline GAB2 siRNA oligo Duplex | 101101410 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo485167 | Pre-made Dog/Canine GAB2 siRNA oligo Duplex | 485167 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo529346 | Pre-made Bovines/Cattle GAB2 siRNA oligo Duplex | 529346 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100062877 | Pre-made Equine/Horse GAB2 siRNA oligo Duplex | 100062877 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GAB2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP2135-Ab | Human | Anti-Human GAB2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP2135-Ab | Rat | Anti-Rat GAB2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP2135-Ab | Mouse | Anti-Mouse GAB2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP2135-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GAB2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP2135-Ab | Cat/Feline | Anti-Cat/Feline GAB2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP2135-Ab | Dog/Canine | Anti-Dog/Canine GAB2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP2135-Ab | Bovines/Cattle | Anti-Bovines/Cattle GAB2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP2135-Ab | Equine/Horse | Anti-Equine/Horse GAB2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
GAB2 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP2135-Ag | Human | Human GAB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP2135-Ag | Rat | Rat GAB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP2135-Ag | Mouse | Mouse GAB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP2135-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GAB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP2135-Ag | Cat/Feline | Cat/Feline GAB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP2135-Ag | Dog/Canine | Dog/Canine GAB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP2135-Ag | Bovines/Cattle | Bovines/Cattle GAB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP2135-Ag | Equine/Horse | Equine/Horse GAB2 VLP (virus-like particle) | HEK293 | Products Developing |
