Explore AXIN2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP2013
|
| Target Name |
AXIN2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
8313
|
| Gene ID |
100630049 (Equus caballus), 101093061 (Felis catus), 12006 (Mus musculus), 29134 (Rattus norvegicus)
490903 (Canis lupus familiaris), 511619 (Bos taurus), 718566 (Macaca mulatta), 8313 (Homo sapiens)
|
| Target Alternative Names |
AXIN2,Axin2,Axi1,Axil,Conductin,axil,axin-2,AXIL,ODCRCS
|
| Uniprot Accession |
O88566,O70240,Q9Y2T1
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
|
| Disease |
cancer
|
| Disease from KEGG |
Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Cushing syndrome, Alzheimer disease, Human papillomavirus infection, Pathways in cancer, Colorectal cancer, Endometrial cancer, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer
|
| Gene Ensembl |
ENSECAG00000017986, ENSMUSG00000000142, ENSCAFG00845028532, ENSBTAG00000030162, ENSMMUG00000060015, ENSG00000168646
|
| Target Classification |
Tumor-associated antigen (TAA)
|
AXIN2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8313 | Pre-made Human AXIN2/AXIL/ODCRCS siRNA oligo Duplex | 8313 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29134 | Pre-made Rat Axin2/axil/axin-2 siRNA oligo Duplex | 29134 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12006 | Pre-made Mouse Axin2/Axi1/Axil siRNA oligo Duplex | 12006 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo718566 | Pre-made Cynomolgus/Rhesus macaque AXIN2/axin-2 siRNA oligo Duplex | 718566 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101093061 | Pre-made Cat/Feline AXIN2 siRNA oligo Duplex | 101093061 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo490903 | Pre-made Dog/Canine AXIN2 siRNA oligo Duplex | 490903 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo511619 | Pre-made Bovines/Cattle AXIN2 siRNA oligo Duplex | 511619 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100630049 | Pre-made Equine/Horse AXIN2 siRNA oligo Duplex | 100630049 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
AXIN2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP2013-Ab | Human | Anti-Human AXIN2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP2013-Ab | Rat | Anti-Rat AXIN2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP2013-Ab | Mouse | Anti-Mouse AXIN2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP2013-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque AXIN2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP2013-Ab | Cat/Feline | Anti-Cat/Feline AXIN2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP2013-Ab | Dog/Canine | Anti-Dog/Canine AXIN2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP2013-Ab | Bovines/Cattle | Anti-Bovines/Cattle AXIN2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP2013-Ab | Equine/Horse | Anti-Equine/Horse AXIN2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
AXIN2 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP2013-Ag | Human | Human AXIN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP2013-Ag | Rat | Rat AXIN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP2013-Ag | Mouse | Mouse AXIN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP2013-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque AXIN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP2013-Ag | Cat/Feline | Cat/Feline AXIN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP2013-Ag | Dog/Canine | Dog/Canine AXIN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP2013-Ag | Bovines/Cattle | Bovines/Cattle AXIN2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP2013-Ag | Equine/Horse | Equine/Horse AXIN2 VLP (virus-like particle) | HEK293 | Products Developing |
