Explore ANK3 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
| Target ID |
GM-MP1989
|
| Target Name |
ANK3
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
288
|
| Gene ID |
100062775 (Equus caballus), 101097842 (Felis catus), 11735 (Mus musculus), 288 (Homo sapiens) 361833 (Rattus norvegicus), 479215 (Canis lupus familiaris), 511203 (Bos taurus), 699518 (Macaca mulatta)
|
| Target Alternative Names |
2900054D09Rik,ANK-3,ANK3,ANKYRIN-G,Ank-3,Ank3,AnkG,Ankyrin-3,Ankyrin-G,MRT37
|
| Uniprot Accession |
G5E8K5,Q12955,O70511
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease from KEGG |
Proteoglycans in cancer
|
| Gene Ensembl |
ENSECAG00000009700, ENSMUSG00000069601, ENSG00000151150, ENSCAFG00845002592, ENSBTAG00000019052, ENSMMUG00000003589
|
ANK3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo288 | Pre-made Human ANK3/MRT37/ANKYRIN-G siRNA oligo Duplex | 288 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo361833 | Pre-made Rat Ank3/ANK-3 siRNA oligo Duplex | 361833 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11735 | Pre-made Mouse Ank3/AnkG/Ank-3 siRNA oligo Duplex | 11735 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699518 | Pre-made Cynomolgus/Rhesus macaque ANK3 siRNA oligo Duplex | 699518 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101097842 | Pre-made Cat/Feline ANK3 siRNA oligo Duplex | 101097842 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo479215 | Pre-made Dog/Canine ANK3 siRNA oligo Duplex | 479215 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo511203 | Pre-made Bovines/Cattle ANK3 siRNA oligo Duplex | 511203 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100062775 | Pre-made Equine/Horse ANK3 siRNA oligo Duplex | 100062775 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ANK3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP1989-Ab | Human | Anti-Human ANK3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP1989-Ab | Rat | Anti-Rat ANK3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP1989-Ab | Mouse | Anti-Mouse ANK3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP1989-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ANK3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP1989-Ab | Cat/Feline | Anti-Cat/Feline ANK3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP1989-Ab | Dog/Canine | Anti-Dog/Canine ANK3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP1989-Ab | Bovines/Cattle | Anti-Bovines/Cattle ANK3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP1989-Ab | Equine/Horse | Anti-Equine/Horse ANK3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
ANK3 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP1989-Ag | Human | Human ANK3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP1989-Ag | Rat | Rat ANK3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP1989-Ag | Mouse | Mouse ANK3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP1989-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ANK3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP1989-Ag | Cat/Feline | Cat/Feline ANK3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP1989-Ag | Dog/Canine | Dog/Canine ANK3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP1989-Ag | Bovines/Cattle | Bovines/Cattle ANK3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP1989-Ag | Equine/Horse | Equine/Horse ANK3 VLP (virus-like particle) | HEK293 | Products Developing |