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Target
sublocation: Transmembrane Protein.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP1936
|
| Target Name |
WNT4
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
54361
|
| Gene ID |
100071678 (Equus caballus), 101095185 (Felis catus), 22417 (Mus musculus), 54361 (Homo sapiens) 612367 (Canis lupus familiaris), 707864 (Macaca mulatta), 789600 (Bos taurus), 84426 (Rattus norvegicus)
|
| Target Alternative Names |
Protein Wnt-4,SERKAL,WNT-4,WNT4,Wnt-4,Wnt4
|
| Uniprot Accession |
P22724,P56705,Q9QXQ5
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Cytokine Target
|
| Disease |
cancer, Injury to Kidney
|
| Disease from KEGG |
Wnt signaling pathway, Axon guidance, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Melanogenesis, Thyroid hormone signaling pathway, Cushing syndrome, Alzheimer disease, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer
|
| Gene Ensembl |
ENSECAG00000018933, ENSMUSG00000036856, ENSG00000162552, ENSCAFG00845000755, ENSMMUG00000061414, ENSBTAG00000051083
|
Pre-made viral vector of WNT4 cDNA Clones/ORF Plasmid
WNT4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo54361 | Pre-made Human WNT4/WNT-4/SERKAL siRNA oligo Duplex | 54361 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo84426 | Pre-made Rat Wnt4 siRNA oligo Duplex | 84426 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22417 | Pre-made Mouse Wnt4/Wnt-4 siRNA oligo Duplex | 22417 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo707864 | Pre-made Cynomolgus/Rhesus macaque WNT4 siRNA oligo Duplex | 707864 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095185 | Pre-made Cat/Feline WNT4 siRNA oligo Duplex | 101095185 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo612367 | Pre-made Dog/Canine WNT4 siRNA oligo Duplex | 612367 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo789600 | Pre-made Bovines/Cattle WNT4 siRNA oligo Duplex | 789600 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100071678 | Pre-made Equine/Horse WNT4 siRNA oligo Duplex | 100071678 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
WNT4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP1936-Ab | Human | Anti-Human WNT4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-rg-MP1936-Ab | Rat | Anti-Rat WNT4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-mg-MP1936-Ab | Mouse | Anti-Mouse WNT4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-MP1936-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque WNT4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-felg-MP1936-Ab | Cat/Feline | Anti-Cat/Feline WNT4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-cang-MP1936-Ab | Dog/Canine | Anti-Dog/Canine WNT4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-MP1936-Ab | Bovines/Cattle | Anti-Bovines/Cattle WNT4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-equg-MP1936-Ab | Equine/Horse | Anti-Equine/Horse WNT4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
WNT4 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP1936-Ag | Human | Human WNT4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP1936-Ag | Rat | Rat WNT4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP1936-Ag | Mouse | Mouse WNT4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP1936-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque WNT4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP1936-Ag | Cat/Feline | Cat/Feline WNT4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP1936-Ag | Dog/Canine | Dog/Canine WNT4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP1936-Ag | Bovines/Cattle | Bovines/Cattle WNT4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP1936-Ag | Equine/Horse | Equine/Horse WNT4 VLP (virus-like particle) | HEK293 | Products Developing |