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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP1854
|
| Target Name |
DcR1/TNFRSF10C/CD263
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
8794
|
| Gene ID |
100430035 (Macaca mulatta), 8794 (Homo sapiens)
|
| Target Alternative Names |
Antagonist decoy receptor for TRAIL/Apo-2L,CD263,DCR1,DCR1-TNFR,DcR1,Decoy TRAIL receptor without death domain,Decoy receptor 1 (DcR1),LIT,Lymphocyte inhibitor of TRAIL,TNF-related apoptosis-inducing ligand receptor 3 (TRAIL receptor 3,TNFRSF10C,TRAIL receptor without an intracellular domain,TRAIL-R3,TRAIL-R3),TRAILR3,TRID,Tumor necrosis factor receptor superfamily member 10C
|
| Uniprot Accession |
O14798
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor
|
| Gene Ensembl |
ENSG00000173535
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of DcR1/TNFRSF10C/CD263 cDNA Clones/ORF Plasmid
DcR1/TNFRSF10C/CD263 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8794 | Pre-made Human TNFRSF10C/LIT/DCR1 siRNA oligo Duplex | 8794 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100430035 | Pre-made Cynomolgus/Rhesus macaque TNFRSF10C siRNA oligo Duplex | 100430035 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
DcR1/TNFRSF10C/CD263 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP1854-Ab | Human | Anti-Human DcR1/TNFRSF10C/CD263 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-MP1854-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque DcR1/TNFRSF10C/CD263 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
DcR1/TNFRSF10C/CD263 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP1854-Ag | Human | Human DcR1/TNFRSF10C/CD263 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP1854-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque DcR1/TNFRSF10C/CD263 VLP (virus-like particle) | HEK293 | Products Developing |
