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Target
sublocation: Transmembrane Protein.
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010]
| Target ID |
GM-MP1525
|
| Target Name |
Siglec-8/SIGLEC8
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
27181
|
| Gene ID |
27181 (Homo sapiens)
|
| Target Alternative Names |
SAF2,SIGLEC-8,SIGLEC8,SIGLEC8L,Sialic acid-binding Ig-like lectin 8,Sialoadhesin family member 2 (SAF-2),Siglec-8
|
| Uniprot Accession |
Q9NYZ4
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Gene Ensembl |
ENSG00000105366
|
Siglec-8/SIGLEC8 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo27181 | Pre-made Human SIGLEC8/SAF2/SIGLEC-8 siRNA oligo Duplex | 27181 | Human | In-vitro grade; in-vivo grade | Detail |
Siglec-8/SIGLEC8 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP1525-Ab | Human | Anti-Human Siglec-8/SIGLEC8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Siglec-8/SIGLEC8 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP1525-Ag | Human | Human Siglec-8/SIGLEC8 VLP (virus-like particle) | HEK293 | Products Developing |
