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Target
sublocation: Transmembrane Protein.
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
| Target ID |
GM-MP1520
|
| Target Name |
Siglec-12/SIGLEC12
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
89858
|
| Gene ID |
719654 (Macaca mulatta), 89858 (Homo sapiens)
|
| Target Alternative Names |
S2V,SIGLEC12,SIGLECL1,SLG,Sialic acid-binding Ig-like lectin 12,Sialic acid-binding Ig-like lectin-like 1 (Siglec-L1),Siglec-12,Siglec-XII
|
| Uniprot Accession |
Q96PQ1
|
| Protein Sub-location |
Transmembrane Protein
|
| Gene Ensembl |
ENSG00000254521
|
Siglec-12/SIGLEC12 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo89858 | Pre-made Human SIGLEC12/S2V/SLG siRNA oligo Duplex | 89858 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo719654 | Pre-made Cynomolgus/Rhesus macaque SIGLEC12 siRNA oligo Duplex | 719654 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
Siglec-12/SIGLEC12 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP1520-Ab | Human | Anti-Human Siglec-12/SIGLEC12 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP1520-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Siglec-12/SIGLEC12 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
Siglec-12/SIGLEC12 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP1520-Ag | Human | Human Siglec-12/SIGLEC12 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP1520-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Siglec-12/SIGLEC12 VLP (virus-like particle) | HEK293 | Products Developing |
