Explore SCN1A gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
Voltage-dependent sodium channels are heteromeric complexes that regulate sodium exchange between intracellular and extracellular spaces and are essential for the generation and propagation of action potentials in muscle cells and neurons. Each sodium channel is composed of a large pore-forming, glycosylated alpha subunit and two smaller beta subunits. This gene encodes a sodium channel alpha subunit, which has four homologous domains, each of which contains six transmembrane regions. Allelic variants of this gene are associated with generalized epilepsy with febrile seizures and epileptic encephalopathy. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript. [provided by RefSeq, Oct 2015]
| Target ID |
GM-MP1486
|
| Target Name |
SCN1A
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
6323
|
| Gene ID |
100052059 (Equus caballus), 101081823 (Felis catus), 20265 (Mus musculus), 6323 (Homo sapiens)
704086 (Macaca mulatta), 81574 (Rattus norvegicus)
|
| Target Alternative Names |
B230332M13,DEE6,DEE6A,DEE6B,DRVT,EIEE6,FEB3,FEB3A,FHM3,GEFSP2,HBSCI,NAC1,Nav1.1,SCN1,SCN1A,SMEI,Scn1a,Sodium channel protein brain I subunit alpha,Sodium channel protein type 1 subunit alpha,Sodium channel protein type I subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.1
|
| Uniprot Accession |
A2APX8,P35498,P04774
|
| Protein Sub-location |
Transmembrane Protein
|
| Gene Ensembl |
ENSECAG00000015359, ENSMUSG00000064329, ENSG00000144285, ENSMMUG00000008407
|
| Target Classification |
Ion Channel
|
SCN1A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6323 | Pre-made Human SCN1A/DEE6/DRVT siRNA oligo Duplex | 6323 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo81574 | Pre-made Rat Scn1a siRNA oligo Duplex | 81574 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20265 | Pre-made Mouse Scn1a/Nav1.1/B230332M13 siRNA oligo Duplex | 20265 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo704086 | Pre-made Cynomolgus/Rhesus macaque SCN1A siRNA oligo Duplex | 704086 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101081823 | Pre-made Cat/Feline SCN1A siRNA oligo Duplex | 101081823 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052059 | Pre-made Equine/Horse SCN1A siRNA oligo Duplex | 100052059 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SCN1A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP1486-Ab | Human | Anti-Human SCN1A monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP1486-Ab | Rat | Anti-Rat SCN1A monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP1486-Ab | Mouse | Anti-Mouse SCN1A monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP1486-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SCN1A monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP1486-Ab | Cat/Feline | Anti-Cat/Feline SCN1A monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP1486-Ab | Equine/Horse | Anti-Equine/Horse SCN1A monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
SCN1A VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP1486-Ag | Human | Human SCN1A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP1486-Ag | Rat | Rat SCN1A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP1486-Ag | Mouse | Mouse SCN1A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP1486-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SCN1A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP1486-Ag | Cat/Feline | Cat/Feline SCN1A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP1486-Ag | Equine/Horse | Equine/Horse SCN1A VLP (virus-like particle) | HEK293 | Products Developing |
