Explore PTPRT gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP1437
|
| Target Name |
PTPRT
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
11122
|
| Gene ID |
100070624 (Equus caballus), 101091931 (Felis catus), 11122 (Homo sapiens), 19281 (Mus musculus)
362263 (Rattus norvegicus), 485878 (Canis lupus familiaris), 524059 (Bos taurus), 696796 (Macaca mulatta)
|
| Target Alternative Names |
PTPRT,Ptprt,R-PTP-T,RPTP-rfo,RPTP-rho,RPTPmam4,RPTPrho,Receptor-type tyrosine-protein phosphatase T,Receptor-type tyrosine-protein phosphatase rho (RPTP-rho),mKIAA0283,mRPTPrho
|
| Uniprot Accession |
O14522,Q99M80
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000021728, ENSG00000196090, ENSMUSG00000053141, ENSCAFG00845011487, ENSBTAG00000000309, ENSMMUG00000001108
|
| Target Classification |
Tumor-associated antigen (TAA)
|
PTPRT siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo11122 | Pre-made Human PTPRT/R-PTP-T/RPTPrho siRNA oligo Duplex | 11122 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo362263 | Pre-made Rat Ptprt siRNA oligo Duplex | 362263 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19281 | Pre-made Mouse Ptprt/R-PTP-T/RPTPrho siRNA oligo Duplex | 19281 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo696796 | Pre-made Cynomolgus/Rhesus macaque PTPRT siRNA oligo Duplex | 696796 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101091931 | Pre-made Cat/Feline PTPRT siRNA oligo Duplex | 101091931 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo485878 | Pre-made Dog/Canine PTPRT siRNA oligo Duplex | 485878 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo524059 | Pre-made Bovines/Cattle PTPRT siRNA oligo Duplex | 524059 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100070624 | Pre-made Equine/Horse PTPRT siRNA oligo Duplex | 100070624 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PTPRT antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP1437-Ab | Human | Anti-Human PTPRT monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP1437-Ab | Rat | Anti-Rat PTPRT monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP1437-Ab | Mouse | Anti-Mouse PTPRT monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP1437-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PTPRT monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP1437-Ab | Cat/Feline | Anti-Cat/Feline PTPRT monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP1437-Ab | Dog/Canine | Anti-Dog/Canine PTPRT monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP1437-Ab | Bovines/Cattle | Anti-Bovines/Cattle PTPRT monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP1437-Ab | Equine/Horse | Anti-Equine/Horse PTPRT monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
PTPRT VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP1437-Ag | Human | Human PTPRT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP1437-Ag | Rat | Rat PTPRT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP1437-Ag | Mouse | Mouse PTPRT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP1437-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PTPRT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP1437-Ag | Cat/Feline | Cat/Feline PTPRT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP1437-Ag | Dog/Canine | Dog/Canine PTPRT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP1437-Ag | Bovines/Cattle | Bovines/Cattle PTPRT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP1437-Ag | Equine/Horse | Equine/Horse PTPRT VLP (virus-like particle) | HEK293 | Products Developing |
