Explore IA-2/PTPRN gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
| Target ID |
GM-MP1433
|
| Target Name |
IA-2/PTPRN
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5798
|
| Gene ID |
100056346 (Equus caballus), 101100657 (Felis catus), 116660 (Rattus norvegicus), 19275 (Mus musculus)
286810 (Bos taurus), 478921 (Canis lupus familiaris), 5798 (Homo sapiens), 702826 (Macaca mulatta)
|
| Target Alternative Names |
BEM-3,IA-2,IA-2/PTP,IA2,ICA105,ICA512,Ia-2,Islet cell antigen 512 (ICA 512),Islet cell autoantigen 3,PTP IA-2,PTPLP,PTPRN,Ptprn,R-PTP-N,Receptor-type tyrosine-protein phosphatase-like N,mIA-A,mKIAA4064
|
| Uniprot Accession |
Q63259,Q60673,P56722,Q16849
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease from KEGG |
Type I diabetes mellitus
|
| Gene Ensembl |
ENSECAG00000005468, ENSMUSG00000026204, ENSBTAG00000013798, ENSCAFG00845030025, ENSG00000054356, ENSMMUG00000012008
|
IA-2/PTPRN siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5798 | Pre-made Human PTPRN/IA2/IA-2 siRNA oligo Duplex | 5798 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo116660 | Pre-made Rat Ptprn/Ia-2/BEM-3 siRNA oligo Duplex | 116660 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19275 | Pre-made Mouse Ptprn/IA-2/mIA-A siRNA oligo Duplex | 19275 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo702826 | Pre-made Cynomolgus/Rhesus macaque PTPRN siRNA oligo Duplex | 702826 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100657 | Pre-made Cat/Feline PTPRN siRNA oligo Duplex | 101100657 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo478921 | Pre-made Dog/Canine PTPRN/IA-2 siRNA oligo Duplex | 478921 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo286810 | Pre-made Bovines/Cattle PTPRN siRNA oligo Duplex | 286810 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100056346 | Pre-made Equine/Horse PTPRN siRNA oligo Duplex | 100056346 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IA-2/PTPRN antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP1433-Ab | Human | Anti-Human IA-2/PTPRN monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP1433-Ab | Rat | Anti-Rat IA-2/PTPRN monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP1433-Ab | Mouse | Anti-Mouse IA-2/PTPRN monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP1433-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IA-2/PTPRN monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP1433-Ab | Cat/Feline | Anti-Cat/Feline IA-2/PTPRN monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP1433-Ab | Dog/Canine | Anti-Dog/Canine IA-2/PTPRN monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP1433-Ab | Bovines/Cattle | Anti-Bovines/Cattle IA-2/PTPRN monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP1433-Ab | Equine/Horse | Anti-Equine/Horse IA-2/PTPRN monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
IA-2/PTPRN VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP1433-Ag | Human | Human IA-2/PTPRN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP1433-Ag | Rat | Rat IA-2/PTPRN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP1433-Ag | Mouse | Mouse IA-2/PTPRN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP1433-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IA-2/PTPRN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP1433-Ag | Cat/Feline | Cat/Feline IA-2/PTPRN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP1433-Ag | Dog/Canine | Dog/Canine IA-2/PTPRN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP1433-Ag | Bovines/Cattle | Bovines/Cattle IA-2/PTPRN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP1433-Ag | Equine/Horse | Equine/Horse IA-2/PTPRN VLP (virus-like particle) | HEK293 | Products Developing |
