Explore PTCH1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. [provided by RefSeq, Aug 2017]
| Target ID |
GM-MP1421
|
| Target Name |
PTCH1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5727
|
| Gene ID |
100033936 (Equus caballus), 101085077 (Felis catus), 19206 (Mus musculus), 484137 (Canis lupus familiaris)
520994 (Bos taurus), 5727 (Homo sapiens), 718751 (Macaca mulatta), 89830 (Rattus norvegicus)
|
| Target Alternative Names |
PTCH1,Ptch1,Ptc,mes,wig,Ptc1,Ptch,A230106A15Rik,PTC,BCNS,PTC1,PTCH,BCNS1,NBCCS,Ptch2
|
| Uniprot Accession |
Q61115,Q13635
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
|
| Disease |
cancer
|
| Disease from KEGG |
cAMP signaling pathway, Axon guidance, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma
|
| Gene Ensembl |
ENSECAG00000000141, ENSMUSG00000021466, ENSCAFG00845003905, ENSBTAG00000009903, ENSG00000185920, ENSMMUG00000002634
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of PTCH1 cDNA Clones/ORF Plasmid
PTCH1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5727 | Pre-made Human PTCH1/PTC/BCNS siRNA oligo Duplex | 5727 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo89830 | Pre-made Rat Ptch1/Ptch/Ptch2 siRNA oligo Duplex | 89830 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19206 | Pre-made Mouse Ptch1/Ptc/mes siRNA oligo Duplex | 19206 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo718751 | Pre-made Cynomolgus/Rhesus macaque PTCH1 siRNA oligo Duplex | 718751 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085077 | Pre-made Cat/Feline PTCH1 siRNA oligo Duplex | 101085077 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo484137 | Pre-made Dog/Canine PTCH1 siRNA oligo Duplex | 484137 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo520994 | Pre-made Bovines/Cattle PTCH1 siRNA oligo Duplex | 520994 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100033936 | Pre-made Equine/Horse PTCH1 siRNA oligo Duplex | 100033936 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PTCH1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP1421-Ab | Human | Anti-Human PTCH1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP1421-Ab | Rat | Anti-Rat PTCH1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP1421-Ab | Mouse | Anti-Mouse PTCH1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP1421-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PTCH1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP1421-Ab | Cat/Feline | Anti-Cat/Feline PTCH1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP1421-Ab | Dog/Canine | Anti-Dog/Canine PTCH1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP1421-Ab | Bovines/Cattle | Anti-Bovines/Cattle PTCH1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP1421-Ab | Equine/Horse | Anti-Equine/Horse PTCH1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
PTCH1 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP1421-Ag | Human | Human PTCH1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP1421-Ag | Rat | Rat PTCH1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP1421-Ag | Mouse | Mouse PTCH1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP1421-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PTCH1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP1421-Ag | Cat/Feline | Cat/Feline PTCH1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP1421-Ag | Dog/Canine | Dog/Canine PTCH1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP1421-Ag | Bovines/Cattle | Bovines/Cattle PTCH1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP1421-Ag | Equine/Horse | Equine/Horse PTCH1 VLP (virus-like particle) | HEK293 | Products Developing |
