Explore PSAP gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
| Target ID |
GM-MP1417
|
| Target Name |
PSAP
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5660
|
| Gene ID |
100063520 (Equus caballus), 101080406 (Felis catus), 19156 (Mus musculus), 25524 (Rattus norvegicus) 281433 (Bos taurus), 479240 (Canis lupus familiaris), 5660 (Homo sapiens), 709510 (Macaca mulatta)
|
| Target Alternative Names |
GLBA,PARK24,PSAP,PSAPD,Proactivator polypeptide,Prosaposin,Psap,SAP1,SAP2,SGP-1,SGP1A
|
| Uniprot Accession |
Q61207,P10960,P26779,P07602
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease |
Ovary Cancer, Malignant neoplasm of bladder
|
| Disease from KEGG |
Lysosome, Sphingolipid metabolism
|
| Gene Ensembl |
ENSECAG00000021672, ENSMUSG00000004207, ENSBTAG00000021499, ENSCAFG00845004604, ENSG00000197746, ENSMMUG00000012969
|
Pre-made viral vector of PSAP cDNA Clones/ORF Plasmid
PSAP siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5660 | Pre-made Human PSAP/GLBA/SAP1 siRNA oligo Duplex | 5660 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25524 | Pre-made Rat Psap/SGP-1/SGP1A siRNA oligo Duplex | 25524 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19156 | Pre-made Mouse Psap/SGP-1 siRNA oligo Duplex | 19156 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo709510 | Pre-made Cynomolgus/Rhesus macaque PSAP siRNA oligo Duplex | 709510 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101080406 | Pre-made Cat/Feline PSAP siRNA oligo Duplex | 101080406 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo479240 | Pre-made Dog/Canine PSAP siRNA oligo Duplex | 479240 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281433 | Pre-made Bovines/Cattle PSAP siRNA oligo Duplex | 281433 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100063520 | Pre-made Equine/Horse PSAP siRNA oligo Duplex | 100063520 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PSAP antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP1417-Ab | Human | Anti-Human PSAP monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP1417-Ab | Rat | Anti-Rat PSAP monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP1417-Ab | Mouse | Anti-Mouse PSAP monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP1417-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PSAP monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP1417-Ab | Cat/Feline | Anti-Cat/Feline PSAP monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP1417-Ab | Dog/Canine | Anti-Dog/Canine PSAP monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP1417-Ab | Bovines/Cattle | Anti-Bovines/Cattle PSAP monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP1417-Ab | Equine/Horse | Anti-Equine/Horse PSAP monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
PSAP VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP1417-Ag | Human | Human PSAP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP1417-Ag | Rat | Rat PSAP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP1417-Ag | Mouse | Mouse PSAP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP1417-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PSAP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP1417-Ag | Cat/Feline | Cat/Feline PSAP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP1417-Ag | Dog/Canine | Dog/Canine PSAP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP1417-Ag | Bovines/Cattle | Bovines/Cattle PSAP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP1417-Ag | Equine/Horse | Equine/Horse PSAP VLP (virus-like particle) | HEK293 | Products Developing |