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Target
sublocation: Transmembrane Protein.
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP0711
|
| Target Name |
KLRC2/CD159c
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3822
|
| Gene ID |
114670780 (Macaca mulatta), 3822 (Homo sapiens), 503651 (Rattus norvegicus)
|
| Target Alternative Names |
CD159 antigen-like family member C,CD159c,KLRC2,Klri1,NK cell receptor C,NKG2-C,NKG2-C type II integral membrane protein,NKG2-C-activating NK receptor,NKG2C,nkg2C
|
| Uniprot Accession |
Q9MZK6,P26717,Q5DT39
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease from KEGG |
Antigen processing and presentation, Natural killer cell mediated cytotoxicity
|
| Gene Ensembl |
ENSG00000205809
|
Pre-made viral vector of KLRC2/CD159c cDNA Clones/ORF Plasmid
KLRC2/CD159c siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3822 | Pre-made Human KLRC2/NKG2C/CD159c siRNA oligo Duplex | 3822 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo503651 | Pre-made Rat Klri1 siRNA oligo Duplex | 503651 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo114670780 | Pre-made Cynomolgus/Rhesus macaque KLRC2/nkg2C/CD159c siRNA oligo Duplex | 114670780 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
KLRC2/CD159c antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0711-Ab | Human | Anti-Human KLRC2/CD159c monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP0711-Ab | Rat | Anti-Rat KLRC2/CD159c monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP0711-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque KLRC2/CD159c monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
KLRC2/CD159c VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0711-Ag | Human | Human KLRC2/CD159c VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP0711-Ag | Rat | Rat KLRC2/CD159c VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0711-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque KLRC2/CD159c VLP (virus-like particle) | HEK293 | Products Developing |
