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Target
sublocation: Transmembrane Protein.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP0705
|
| Target Name |
KIR3DL3/CD158z
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
115653
|
| Gene ID |
101084434 (Felis catus), 115653 (Homo sapiens)
|
| Target Alternative Names |
CD158 antigen-like family member Z,CD158Z,CD158z,KIR2DL5B,KIR3DL3,KIR3DL7,KIR44,KIRC1,Killer cell immunoglobulin-like receptor 3DL3,Killer cell inhibitory receptor 1
|
| Uniprot Accession |
Q8N743
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease from KEGG |
Antigen processing and presentation, Natural killer cell mediated cytotoxicity, Graft-versus-host disease
|
| Gene Ensembl |
ENSG00000242019
|
KIR3DL3/CD158z siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo115653 | Pre-made Human KIR3DL3/KIR44/KIRC1 siRNA oligo Duplex | 115653 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101084434 | Pre-made Cat/Feline KIR3DL3 siRNA oligo Duplex | 101084434 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
KIR3DL3/CD158z antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0705-Ab | Human | Anti-Human KIR3DL3/CD158z monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP0705-Ab | Cat/Feline | Anti-Cat/Feline KIR3DL3/CD158z monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
KIR3DL3/CD158z VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0705-Ag | Human | Human KIR3DL3/CD158z VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP0705-Ag | Cat/Feline | Cat/Feline KIR3DL3/CD158z VLP (virus-like particle) | HEK293 | Products Developing |
