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Target
sublocation: Transmembrane Protein.
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
| Target ID |
GM-MP0650
|
| Target Name |
JAM3
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
83700
|
| Gene ID |
100072872 (Equus caballus), 101097016 (Felis catus), 315509 (Rattus norvegicus), 489271 (Canis lupus familiaris) 513412 (Bos taurus), 694042 (Macaca mulatta), 83700 (Homo sapiens), 83964 (Mus musculus)
|
| Target Alternative Names |
1110002N23Rik,JAM-2,JAM-3,JAM-C,JAM3,JAMC,Jam3,Jcam3,Junctional adhesion molecule 3 (JAM-3),Junctional adhesion molecule C
|
| Uniprot Accession |
Q68FQ2,Q9BX67,Q9D8B7
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease from KEGG |
Cell adhesion molecules, Tight junction, Leukocyte transendothelial migration, Epithelial cell signaling in Helicobacter pylori infection
|
| Gene Ensembl |
ENSECAG00000015550, ENSCAFG00845005503, ENSBTAG00000003176, ENSMMUG00000007100, ENSG00000166086, ENSMUSG00000031990
|
Pre-made viral vector of JAM3 cDNA Clones/ORF Plasmid
JAM3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo83700 | Pre-made Human JAM3/JAMC/JAM-2 siRNA oligo Duplex | 83700 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo315509 | Pre-made Rat Jam3 siRNA oligo Duplex | 315509 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo83964 | Pre-made Mouse Jam3/JAM-3/JAM-C siRNA oligo Duplex | 83964 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo694042 | Pre-made Cynomolgus/Rhesus macaque JAM3 siRNA oligo Duplex | 694042 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101097016 | Pre-made Cat/Feline JAM3 siRNA oligo Duplex | 101097016 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489271 | Pre-made Dog/Canine JAM3 siRNA oligo Duplex | 489271 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo513412 | Pre-made Bovines/Cattle JAM3 siRNA oligo Duplex | 513412 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100072872 | Pre-made Equine/Horse JAM3 siRNA oligo Duplex | 100072872 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
JAM3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0650-Ab | Human | Anti-Human JAM3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP0650-Ab | Rat | Anti-Rat JAM3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP0650-Ab | Mouse | Anti-Mouse JAM3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP0650-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque JAM3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP0650-Ab | Cat/Feline | Anti-Cat/Feline JAM3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP0650-Ab | Dog/Canine | Anti-Dog/Canine JAM3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP0650-Ab | Bovines/Cattle | Anti-Bovines/Cattle JAM3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP0650-Ab | Equine/Horse | Anti-Equine/Horse JAM3 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
JAM3 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0650-Ag | Human | Human JAM3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP0650-Ag | Rat | Rat JAM3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP0650-Ag | Mouse | Mouse JAM3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0650-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque JAM3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP0650-Ag | Cat/Feline | Cat/Feline JAM3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP0650-Ag | Dog/Canine | Dog/Canine JAM3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP0650-Ag | Bovines/Cattle | Bovines/Cattle JAM3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP0650-Ag | Equine/Horse | Equine/Horse JAM3 VLP (virus-like particle) | HEK293 | Products Developing |