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Target
sublocation: Transmembrane Protein.
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]
| Target ID |
GM-MP0596
|
| Target Name |
HYAL2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
8692
|
| Gene ID |
100061845 (Equus caballus), 15587 (Mus musculus), 281838 (Bos taurus), 484760 (Canis lupus familiaris) 64468 (Rattus norvegicus), 702484 (Macaca mulatta), 8692 (Homo sapiens)
|
| Target Alternative Names |
HYAL2,Hyal-2,Hyal2,Hyaluronidase-2,Hyaluronoglucosaminidase-2,LUCA2,Lung carcinoma protein 2 (LuCa-2)
|
| Uniprot Accession |
O35632,Q8SQG8,Q9Z2Q3,Q12891
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease |
cancer, Lung Cancer
|
| Disease from KEGG |
Metabolic pathways, Lysosome, Glycosaminoglycan degradation
|
| Gene Ensembl |
ENSECAG00000017559, ENSMUSG00000010047, ENSBTAG00000000484, ENSCAFG00845021903, ENSMMUG00000006994, ENSG00000068001
|
Pre-made viral vector of HYAL2 cDNA Clones/ORF Plasmid
HYAL2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8692 | Pre-made Human HYAL2/LUCA2 siRNA oligo Duplex | 8692 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo64468 | Pre-made Rat Hyal2 siRNA oligo Duplex | 64468 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo15587 | Pre-made Mouse Hyal2 siRNA oligo Duplex | 15587 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo702484 | Pre-made Cynomolgus/Rhesus macaque HYAL2 siRNA oligo Duplex | 702484 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo484760 | Pre-made Dog/Canine HYAL2 siRNA oligo Duplex | 484760 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281838 | Pre-made Bovines/Cattle HYAL2 siRNA oligo Duplex | 281838 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100061845 | Pre-made Equine/Horse HYAL2 siRNA oligo Duplex | 100061845 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
HYAL2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0596-Ab | Human | Anti-Human HYAL2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP0596-Ab | Rat | Anti-Rat HYAL2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP0596-Ab | Mouse | Anti-Mouse HYAL2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP0596-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque HYAL2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP0596-Ab | Dog/Canine | Anti-Dog/Canine HYAL2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP0596-Ab | Bovines/Cattle | Anti-Bovines/Cattle HYAL2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP0596-Ab | Equine/Horse | Anti-Equine/Horse HYAL2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
HYAL2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0596-Ag | Human | Human HYAL2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP0596-Ag | Rat | Rat HYAL2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP0596-Ag | Mouse | Mouse HYAL2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0596-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque HYAL2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP0596-Ag | Dog/Canine | Dog/Canine HYAL2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP0596-Ag | Bovines/Cattle | Bovines/Cattle HYAL2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP0596-Ag | Equine/Horse | Equine/Horse HYAL2 VLP (virus-like particle) | HEK293 | Products Developing |