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Target
sublocation: Transmembrane Protein.
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP0588
|
| Target Name |
HLA-E
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3133
|
| Gene ID |
109500088 (Felis catus), 3133 (Homo sapiens)
|
| Target Alternative Names |
HLA class I histocompatibility antigen,HLA-6.2,HLA-E,LOC109500088,MHC class I antigen E,QA1,alpha chain E
|
| Uniprot Accession |
P13747
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease |
cancer
|
| Disease from KEGG |
Phagosome, Cellular senescence, Cell adhesion molecules, Antigen processing and presentation, Type I diabetes mellitus, Human cytomegalovirus infection, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Viral myocarditis
|
| Gene Ensembl |
ENSG00000204592
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of HLA-E cDNA Clones/ORF Plasmid
HLA-E siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3133 | Pre-made Human HLA-E/QA1/HLA-6.2 siRNA oligo Duplex | 3133 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo109500088 | Pre-made Cat/Feline LOC109500088 siRNA oligo Duplex | 109500088 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
HLA-E antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0588-Ab | Human | Anti-Human HLA-E monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP0588-Ab | Cat/Feline | Anti-Cat/Feline HLA-E monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
HLA-E VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0588-Ag | Human | Human HLA-E VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP0588-Ag | Cat/Feline | Cat/Feline HLA-E VLP (virus-like particle) | HEK293 | Products Developing |
