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Target
sublocation: Transmembrane Protein.
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP0584
|
| Target Name |
HLA-DPB1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3115
|
| Gene ID |
111556176 (Felis catus), 3115 (Homo sapiens), 717969 (Macaca mulatta)
|
| Target Alternative Names |
DP beta 1 chain,DP(W4) beta chain,DPB1,HLA class II histocompatibility antigen,HLA-DP,HLA-DP1B,HLA-DPB,HLA-DPB1,LOC111556176,MAMU-DPB,MHC class II antigen DPB1,Mamu-DPB1
|
| Uniprot Accession |
P04440
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease |
cancer
|
| Disease from KEGG |
Phagosome, Cell adhesion molecules, Antigen processing and presentation, Hematopoietic cell lineage, Th1 and Th2 cell differentiation, Th17 cell differentiation, Intestinal immune network for IgA production, Type I diabetes mellitus, Leishmaniasis, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Influenza A, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Viral myocarditis
|
| Gene Ensembl |
ENSG00000223865
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of HLA-DPB1 cDNA Clones/ORF Plasmid
HLA-DPB1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3115 | Pre-made Human HLA-DPB1/DPB1/HLA-DP siRNA oligo Duplex | 3115 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo717969 | Pre-made Cynomolgus/Rhesus macaque MAMU-DPB/Mamu-DPB1 siRNA oligo Duplex | 717969 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo111556176 | Pre-made Cat/Feline LOC111556176 siRNA oligo Duplex | 111556176 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
HLA-DPB1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0584-Ab | Human | Anti-Human HLA-DPB1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP0584-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque HLA-DPB1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP0584-Ab | Cat/Feline | Anti-Cat/Feline HLA-DPB1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
HLA-DPB1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0584-Ag | Human | Human HLA-DPB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0584-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque HLA-DPB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP0584-Ag | Cat/Feline | Cat/Feline HLA-DPB1 VLP (virus-like particle) | HEK293 | Products Developing |
