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Target
sublocation: Transmembrane Protein.
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP0583
|
| Target Name |
HLA-DPA1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3113
|
| Gene ID |
24986 (Rattus norvegicus), 3113 (Homo sapiens), 717992 (Macaca mulatta)
|
| Target Alternative Names |
DP alpha 1 chain,DP(W3),DP(W4),DPA1,HLA class II histocompatibility antigen,HLA-DP1A,HLA-DPA,HLA-DPA1,HLA-DPB1,HLA-SB alpha chain,HLADP,HLASB,MAMU-DPA,MHC class II DP3-alpha,MHC class II DPA1,Mamu-DPA1,PLT1,RT1-Ha,RT1.Ha
|
| Uniprot Accession |
P20036
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease from KEGG |
Phagosome, Cell adhesion molecules, Antigen processing and presentation, Hematopoietic cell lineage, Th1 and Th2 cell differentiation, Th17 cell differentiation, Intestinal immune network for IgA production, Type I diabetes mellitus, Leishmaniasis, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Influenza A, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Viral myocarditis
|
| Gene Ensembl |
ENSG00000231389, ENSMMUG00000019371
|
Pre-made viral vector of HLA-DPA1 cDNA Clones/ORF Plasmid
HLA-DPA1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3113 | Pre-made Human HLA-DPA1/DPA1/PLT1 siRNA oligo Duplex | 3113 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24986 | Pre-made Rat RT1-Ha/RT1.Ha siRNA oligo Duplex | 24986 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo717992 | Pre-made Cynomolgus/Rhesus macaque MAMU-DPA/Mamu-DPA1 siRNA oligo Duplex | 717992 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
HLA-DPA1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0583-Ab | Human | Anti-Human HLA-DPA1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP0583-Ab | Rat | Anti-Rat HLA-DPA1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP0583-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque HLA-DPA1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
HLA-DPA1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0583-Ag | Human | Human HLA-DPA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP0583-Ag | Rat | Rat HLA-DPA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0583-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque HLA-DPA1 VLP (virus-like particle) | HEK293 | Products Developing |
