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Target
sublocation: Transmembrane Protein.
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. About 6000 HLA-C alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020]
| Target ID |
GM-MP0581
|
| Target Name |
HLA-C
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3107
|
| Gene ID |
3107 (Homo sapiens)
|
| Target Alternative Names |
C alpha chain,D6S204,HLA class I histocompatibility antigen,HLA-C,HLA-Cw,HLA-JY3,HLAC,HLC-C,Human leukocyte antigen C,MHC,PSORS1
|
| Uniprot Accession |
P10321
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease |
cancer
|
| Disease from KEGG |
Phagosome, Cellular senescence, Cell adhesion molecules, Antigen processing and presentation, Type I diabetes mellitus, Human cytomegalovirus infection, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Viral myocarditis
|
| Gene Ensembl |
ENSG00000204525
|
| Target Classification |
Tumor-associated antigen (TAA)
|
HLA-C siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3107 | Pre-made Human HLA-C/MHC/HLAC siRNA oligo Duplex | 3107 | Human | In-vitro grade; in-vivo grade | Detail |
HLA-C antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0581-Ab | Human | Anti-Human HLA-C monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
HLA-C VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0581-Ag | Human | Human HLA-C VLP (virus-like particle) | HEK293 | Products Developing |
