Explore GFRA1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
| Target ID |
GM-MP0478
|
| Target Name |
GFRA1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2674
|
| Gene ID |
100067810 (Equus caballus), 101085242 (Felis catus), 14585 (Mus musculus), 25454 (Rattus norvegicus)
2674 (Homo sapiens), 534801 (Bos taurus), 609114 (Canis lupus familiaris), 706353 (Macaca mulatta)
|
| Target Alternative Names |
GDNF family receptor alpha-1,GDNF receptor alpha-1,GDNFR,GDNFR-alpha-1,GDNFRA,GFR-ALPHA-1,GFR-alpha-1,GFRA1,GFRalpha-1,Gfra1,RET ligand 1,RET1L,RETL1,RHDA4,TGF-beta-related neurotrophic factor receptor 1,TRNR1
|
| Uniprot Accession |
P97785,Q62997,P56159
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Cytokine Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000006846, ENSMUSG00000025089, ENSG00000151892, ENSBTAG00000019297, ENSCAFG00845030969, ENSMMUG00000020080
|
Pre-made viral vector of GFRA1 cDNA Clones/ORF Plasmid
GFRA1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2674 | Pre-made Human GFRA1/GDNFR/RET1L siRNA oligo Duplex | 2674 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25454 | Pre-made Rat Gfra1 siRNA oligo Duplex | 25454 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14585 | Pre-made Mouse Gfra1/GFRalpha-1 siRNA oligo Duplex | 14585 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo706353 | Pre-made Cynomolgus/Rhesus macaque GFRA1 siRNA oligo Duplex | 706353 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085242 | Pre-made Cat/Feline GFRA1 siRNA oligo Duplex | 101085242 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo609114 | Pre-made Dog/Canine GFRA1 siRNA oligo Duplex | 609114 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo534801 | Pre-made Bovines/Cattle GFRA1 siRNA oligo Duplex | 534801 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100067810 | Pre-made Equine/Horse GFRA1 siRNA oligo Duplex | 100067810 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GFRA1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0478-Ab | Human | Anti-Human GFRA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-rg-MP0478-Ab | Rat | Anti-Rat GFRA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-mg-MP0478-Ab | Mouse | Anti-Mouse GFRA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-MP0478-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GFRA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-felg-MP0478-Ab | Cat/Feline | Anti-Cat/Feline GFRA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-cang-MP0478-Ab | Dog/Canine | Anti-Dog/Canine GFRA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-MP0478-Ab | Bovines/Cattle | Anti-Bovines/Cattle GFRA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-equg-MP0478-Ab | Equine/Horse | Anti-Equine/Horse GFRA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
GFRA1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0478-Ag | Human | Human GFRA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP0478-Ag | Rat | Rat GFRA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP0478-Ag | Mouse | Mouse GFRA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0478-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GFRA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP0478-Ag | Cat/Feline | Cat/Feline GFRA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP0478-Ag | Dog/Canine | Dog/Canine GFRA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP0478-Ag | Bovines/Cattle | Bovines/Cattle GFRA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP0478-Ag | Equine/Horse | Equine/Horse GFRA1 VLP (virus-like particle) | HEK293 | Products Developing |
