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Target
sublocation: Transmembrane Protein.
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
| Target ID |
GM-MP0424
|
| Target Name |
ERVWE1/ERVW-1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
30816
|
| Gene ID |
114676987 (Macaca mulatta), 30816 (Homo sapiens)
|
| Target Alternative Names |
ENV,ENVW,ERVW-1,ERVWE1,Endogenous retrovirus group W member 1,Env-W,Envelope polyprotein gPr73,Enverin,HERV-7q,HERV-7q Envelope protein,HERV-W envelope protein,HERV-W-ENV,HERV-W_7q21.2 provirus ancestral Env polyprotein,HERV7Q,HERVW,HERVWENV,Syncytin,Syncytin-1
|
| Uniprot Accession |
Q9UQF0
|
| Protein Sub-location |
Transmembrane Protein
|
| Gene Ensembl |
ENSMMUG00000049959, ENSG00000242950
|
ERVWE1/ERVW-1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo30816 | Pre-made Human ERVW-1/ENV/ENVW siRNA oligo Duplex | 30816 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo114676987 | Pre-made Cynomolgus/Rhesus macaque ERVW-1 siRNA oligo Duplex | 114676987 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
ERVWE1/ERVW-1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0424-Ab | Human | Anti-Human ERVWE1/ERVW-1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP0424-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ERVWE1/ERVW-1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
ERVWE1/ERVW-1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0424-Ag | Human | Human ERVWE1/ERVW-1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0424-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ERVWE1/ERVW-1 VLP (virus-like particle) | HEK293 | Products Developing |
