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Target
sublocation: Transmembrane Protein.
Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP0396
|
| Target Name |
EFNA5
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1946
|
| Gene ID |
100073202 (Equus caballus), 101085951 (Felis catus), 116683 (Rattus norvegicus), 13640 (Mus musculus) 1946 (Homo sapiens), 608458 (Canis lupus familiaris), 616742 (Bos taurus), 704351 (Macaca mulatta)
|
| Target Alternative Names |
AF1,AL-1,EFL-5,EFL5,EFNA5,EPH-related receptor tyrosine kinase ligand 7 (LERK-7),EPLG7,Efna5,Ephrin-A5,Epl7,GLC1M,LERK-7,LERK7,Lerk7,RAGS
|
| Uniprot Accession |
P97605,O08543,P52803
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease |
Breast Cancer
|
| Disease from KEGG |
MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Axon guidance
|
| Gene Ensembl |
ENSECAG00000012062, ENSMUSG00000048915, ENSG00000184349, ENSCAFG00845000512, ENSBTAG00000016515, ENSMMUG00000018398
|
Pre-made viral vector of EFNA5 cDNA Clones/ORF Plasmid
EFNA5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1946 | Pre-made Human EFNA5/AF1/EFL5 siRNA oligo Duplex | 1946 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo116683 | Pre-made Rat Efna5/Lerk7 siRNA oligo Duplex | 116683 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13640 | Pre-made Mouse Efna5/AL-1/Epl7 siRNA oligo Duplex | 13640 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo704351 | Pre-made Cynomolgus/Rhesus macaque EFNA5 siRNA oligo Duplex | 704351 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085951 | Pre-made Cat/Feline EFNA5 siRNA oligo Duplex | 101085951 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo608458 | Pre-made Dog/Canine EFNA5 siRNA oligo Duplex | 608458 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo616742 | Pre-made Bovines/Cattle EFNA5 siRNA oligo Duplex | 616742 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100073202 | Pre-made Equine/Horse EFNA5 siRNA oligo Duplex | 100073202 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
EFNA5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0396-Ab | Human | Anti-Human EFNA5 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP0396-Ab | Rat | Anti-Rat EFNA5 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP0396-Ab | Mouse | Anti-Mouse EFNA5 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP0396-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque EFNA5 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP0396-Ab | Cat/Feline | Anti-Cat/Feline EFNA5 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP0396-Ab | Dog/Canine | Anti-Dog/Canine EFNA5 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP0396-Ab | Bovines/Cattle | Anti-Bovines/Cattle EFNA5 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP0396-Ab | Equine/Horse | Anti-Equine/Horse EFNA5 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
EFNA5 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0396-Ag | Human | Human EFNA5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP0396-Ag | Rat | Rat EFNA5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP0396-Ag | Mouse | Mouse EFNA5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0396-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque EFNA5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP0396-Ag | Cat/Feline | Cat/Feline EFNA5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP0396-Ag | Dog/Canine | Dog/Canine EFNA5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP0396-Ag | Bovines/Cattle | Bovines/Cattle EFNA5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP0396-Ag | Equine/Horse | Equine/Horse EFNA5 VLP (virus-like particle) | HEK293 | Products Developing |