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Target
sublocation: Transmembrane Protein.
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP0372
|
| Target Name |
HLA-DQA1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3117
|
| Gene ID |
14960 (Mus musculus), 3117 (Homo sapiens)
|
| Target Alternative Names |
Aalpha,CELIAC1,DC-1 alpha chain,DC-alpha,DQ alpha 1 chain,DQ-A1,DQA1,H-2Aa,H2-Aa,H2Aa,HLA class II histocompatibility antigen,HLA-DCA,HLA-DQA,HLA-DQA1,HLA-DQA1*,HLA-DQB1,I-Aalpha,IAalpha,Ia-1,Ia1,MHC class II DQA1
|
| Uniprot Accession |
P01910,P04227,P04228,P14434,P14435,P14436,P14437,P14438,P23150,P01909
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease |
cancer
|
| Disease from KEGG |
Phagosome, Cell adhesion molecules, Antigen processing and presentation, Hematopoietic cell lineage, Th1 and Th2 cell differentiation, Th17 cell differentiation, Intestinal immune network for IgA production, Type I diabetes mellitus, Leishmaniasis, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Influenza A, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Viral myocarditis
|
| Gene Ensembl |
ENSMUSG00000036594, ENSG00000196735
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of HLA-DQA1 cDNA Clones/ORF Plasmid
HLA-DQA1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3117 | Pre-made Human HLA-DQA1/DQA1/DQ-A1 siRNA oligo Duplex | 3117 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14960 | Pre-made Mouse H2-Aa/Ia1/H2Aa siRNA oligo Duplex | 14960 | Mouse | In-vitro grade; in-vivo grade | Detail |
HLA-DQA1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0372-Ab | Human | Anti-Human HLA-DQA1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP0372-Ab | Mouse | Anti-Mouse HLA-DQA1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
HLA-DQA1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0372-Ag | Human | Human HLA-DQA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP0372-Ag | Mouse | Mouse HLA-DQA1 VLP (virus-like particle) | HEK293 | Products Developing |
