Explore DMPK gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016]
| Target ID |
GM-MP0363
|
| Target Name |
DMPK
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1760
|
| Gene ID |
100146609 (Equus caballus), 101081940 (Felis catus), 13400 (Mus musculus), 1760 (Homo sapiens)
308405 (Rattus norvegicus), 484436 (Canis lupus familiaris), 513675 (Bos taurus), 715328 (Macaca mulatta)
|
| Target Alternative Names |
DMPK,Dmpk,DM,DMK,Dm15,MDPK,MT-PK,DM1,DM1PK
|
| Uniprot Accession |
P54265,Q09013
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
|
| Disease |
cancer, Prostate Cancer
|
| Disease from KEGG |
|
| Gene Ensembl |
ENSECAG00000016750, ENSMUSG00000030409, ENSG00000104936, ENSCAFG00845004793, ENSBTAG00000013347, ENSMMUG00000016457
|
| Target Classification |
Kinase
|
DMPK siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1760 | Pre-made Human DMPK/DM/DM1 siRNA oligo Duplex | 1760 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo308405 | Pre-made Rat Dmpk/Dm15 siRNA oligo Duplex | 308405 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13400 | Pre-made Mouse Dmpk/DM/DMK siRNA oligo Duplex | 13400 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo715328 | Pre-made Cynomolgus/Rhesus macaque DMPK siRNA oligo Duplex | 715328 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101081940 | Pre-made Cat/Feline DMPK siRNA oligo Duplex | 101081940 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo484436 | Pre-made Dog/Canine DMPK siRNA oligo Duplex | 484436 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo513675 | Pre-made Bovines/Cattle DMPK siRNA oligo Duplex | 513675 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100146609 | Pre-made Equine/Horse DMPK siRNA oligo Duplex | 100146609 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
DMPK antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0363-Ab | Human | Anti-Human DMPK monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP0363-Ab | Rat | Anti-Rat DMPK monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP0363-Ab | Mouse | Anti-Mouse DMPK monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP0363-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque DMPK monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP0363-Ab | Cat/Feline | Anti-Cat/Feline DMPK monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP0363-Ab | Dog/Canine | Anti-Dog/Canine DMPK monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP0363-Ab | Bovines/Cattle | Anti-Bovines/Cattle DMPK monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP0363-Ab | Equine/Horse | Anti-Equine/Horse DMPK monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
DMPK VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0363-Ag | Human | Human DMPK VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP0363-Ag | Rat | Rat DMPK VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP0363-Ag | Mouse | Mouse DMPK VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0363-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque DMPK VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP0363-Ag | Cat/Feline | Cat/Feline DMPK VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP0363-Ag | Dog/Canine | Dog/Canine DMPK VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP0363-Ag | Bovines/Cattle | Bovines/Cattle DMPK VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP0363-Ag | Equine/Horse | Equine/Horse DMPK VLP (virus-like particle) | HEK293 | Products Developing |
