Explore DCC gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
| Target ID |
GM-MP0349
|
| Target Name |
DCC
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1630
|
| Gene ID |
100054013 (Equus caballus), 101098832 (Felis catus), 13176 (Mus musculus), 1630 (Homo sapiens)
25311 (Rattus norvegicus), 483976 (Canis lupus familiaris), 537176 (Bos taurus), 693352 (Macaca mulatta)
|
| Target Alternative Names |
C030036D22Rik,CRC18,CRCR1,Colorectal cancer suppressor,DCC,Dcc,HGPPS2,IGDCC1,Igdcc1,Immunoglobulin superfamily DCC subclass member 1,MRMV1,NTN1R1,Netrin receptor DCC,Tumor suppressor protein DCC
|
| Uniprot Accession |
P70211,P43146,Q63155
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease |
cancer, Colon cancer
|
| Disease from KEGG |
Axon guidance, Pathways in cancer, Colorectal cancer
|
| Gene Ensembl |
ENSECAG00000021760, ENSMUSG00000060534, ENSG00000187323, ENSCAFG00845003053, ENSBTAG00000048378, ENSMMUG00000013999
|
DCC siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1630 | Pre-made Human DCC/CRC18/CRCR1 siRNA oligo Duplex | 1630 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25311 | Pre-made Rat Dcc siRNA oligo Duplex | 25311 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13176 | Pre-made Mouse Dcc/Igdcc1/C030036D22Rik siRNA oligo Duplex | 13176 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo693352 | Pre-made Cynomolgus/Rhesus macaque DCC siRNA oligo Duplex | 693352 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101098832 | Pre-made Cat/Feline DCC siRNA oligo Duplex | 101098832 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo483976 | Pre-made Dog/Canine DCC siRNA oligo Duplex | 483976 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo537176 | Pre-made Bovines/Cattle DCC siRNA oligo Duplex | 537176 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100054013 | Pre-made Equine/Horse DCC siRNA oligo Duplex | 100054013 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
DCC antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0349-Ab | Human | Anti-Human DCC monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP0349-Ab | Rat | Anti-Rat DCC monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP0349-Ab | Mouse | Anti-Mouse DCC monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP0349-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque DCC monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP0349-Ab | Cat/Feline | Anti-Cat/Feline DCC monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP0349-Ab | Dog/Canine | Anti-Dog/Canine DCC monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP0349-Ab | Bovines/Cattle | Anti-Bovines/Cattle DCC monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP0349-Ab | Equine/Horse | Anti-Equine/Horse DCC monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
DCC VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0349-Ag | Human | Human DCC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP0349-Ag | Rat | Rat DCC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP0349-Ag | Mouse | Mouse DCC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0349-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque DCC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP0349-Ag | Cat/Feline | Cat/Feline DCC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP0349-Ag | Dog/Canine | Dog/Canine DCC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP0349-Ag | Bovines/Cattle | Bovines/Cattle DCC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP0349-Ag | Equine/Horse | Equine/Horse DCC VLP (virus-like particle) | HEK293 | Products Developing |
