Explore Cystatin C/CST3 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Nov 2014]
| Target ID |
GM-MP0338
|
| Target Name |
Cystatin C/CST3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1471
|
| Gene ID |
100058494 (Equus caballus), 1471 (Homo sapiens), 574313 (Macaca mulatta)
|
| Target Alternative Names |
ARMD11,CST3,Cystatin C,Cystatin-3,Cystatin-C,Gamma-trace,HEL-S-2,Neuroendocrine basic polypeptide,Post-gamma-globulin
|
| Uniprot Accession |
P01034,O19092
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Diagnostics Biomarker
|
| Disease |
carcinoma, Diabetic Nephropathy, Nephrotoxicity, Sjogren's syndrome salivary, Perinatal necrotizing enterocolitis, Acute kidney failure, Asphyxia neonatorum, Dent disease, Metabolic syndrome, Nephropathy induced by heavy metals, Renal fibrosis
|
| Disease from KEGG |
Salivary secretion
|
| Gene Ensembl |
ENSECAG00000038893, ENSG00000101439, ENSMMUG00000050596
|
Pre-made viral vector of Cystatin C/CST3 cDNA Clones/ORF Plasmid
Cystatin C/CST3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1471 | Pre-made Human CST3/ARMD11/HEL-S-2 siRNA oligo Duplex | 1471 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574313 | Pre-made Cynomolgus/Rhesus macaque CST3 siRNA oligo Duplex | 574313 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100058494 | Pre-made Equine/Horse CST3 siRNA oligo Duplex | 100058494 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Cystatin C/CST3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0338-Ab | Human | Anti-Human Cystatin C/CST3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody | Detail |
| GM-Tg-cynog-MP0338-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Cystatin C/CST3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody | Detail |
| GM-Tg-equg-MP0338-Ab | Equine/Horse | Anti-Equine/Horse Cystatin C/CST3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody | Detail |
Cystatin C/CST3 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0338-Ag | Human | Human Cystatin C/CST3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0338-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Cystatin C/CST3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP0338-Ag | Equine/Horse | Equine/Horse Cystatin C/CST3 VLP (virus-like particle) | HEK293 | Products Developing |
