Explore CLDN8 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]
| Target ID |
GM-MP0287
|
| Target Name |
CLDN8
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
9073
|
| Gene ID |
100053505 (Equus caballus), 101096909 (Felis catus), 304124 (Rattus norvegicus), 478401 (Canis lupus familiaris)
538761 (Bos taurus), 54420 (Mus musculus), 705345 (Macaca mulatta), 9073 (Homo sapiens)
|
| Target Alternative Names |
CLDN8,Cldn8,Claudin-8,HEL-S-79
|
| Uniprot Accession |
Q9Z260,P56748
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
|
| Disease |
Prostate Cancer
|
| Disease from KEGG |
Cell adhesion molecules, Tight junction, Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Hepatitis C
|
| Gene Ensembl |
ENSECAG00000020713, ENSBTAG00000039820, ENSMUSG00000050520, ENSG00000156284
|
| Target Classification |
|
CLDN8 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo9073 | Pre-made Human CLDN8/HEL-S-79 siRNA oligo Duplex | 9073 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo304124 | Pre-made Rat Cldn8 siRNA oligo Duplex | 304124 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo54420 | Pre-made Mouse Cldn8 siRNA oligo Duplex | 54420 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo705345 | Pre-made Cynomolgus/Rhesus macaque CLDN8/Claudin-8 siRNA oligo Duplex | 705345 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096909 | Pre-made Cat/Feline CLDN8 siRNA oligo Duplex | 101096909 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo478401 | Pre-made Dog/Canine CLDN8 siRNA oligo Duplex | 478401 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo538761 | Pre-made Bovines/Cattle CLDN8 siRNA oligo Duplex | 538761 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100053505 | Pre-made Equine/Horse CLDN8 siRNA oligo Duplex | 100053505 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CLDN8 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0287-Ab | Human | Anti-Human CLDN8 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP0287-Ab | Rat | Anti-Rat CLDN8 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP0287-Ab | Mouse | Anti-Mouse CLDN8 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP0287-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CLDN8 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP0287-Ab | Cat/Feline | Anti-Cat/Feline CLDN8 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP0287-Ab | Dog/Canine | Anti-Dog/Canine CLDN8 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP0287-Ab | Bovines/Cattle | Anti-Bovines/Cattle CLDN8 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP0287-Ab | Equine/Horse | Anti-Equine/Horse CLDN8 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
CLDN8 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0287-Ag | Human | Human CLDN8 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP0287-Ag | Rat | Rat CLDN8 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP0287-Ag | Mouse | Mouse CLDN8 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0287-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CLDN8 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP0287-Ag | Cat/Feline | Cat/Feline CLDN8 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP0287-Ag | Dog/Canine | Dog/Canine CLDN8 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP0287-Ag | Bovines/Cattle | Bovines/Cattle CLDN8 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP0287-Ag | Equine/Horse | Equine/Horse CLDN8 VLP (virus-like particle) | HEK293 | Products Developing |
