Explore C4BPB gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP0162
|
| Target Name |
C4BPB
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
725
|
| Gene ID |
100051218 (Equus caballus), 101095148 (Felis catus), 24236 (Rattus norvegicus), 281652 (Bos taurus)
609285 (Canis lupus familiaris), 693636 (Macaca mulatta), 725 (Homo sapiens)
|
| Target Alternative Names |
C4BP,C4BPB,C4b-binding protein beta chain,C4bp-ps1,C4bpb
|
| Uniprot Accession |
Q63515,Q28066,P20851
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
|
| Disease |
|
| Disease from KEGG |
Complement and coagulation cascades, Pertussis
|
| Gene Ensembl |
ENSBTAG00000017714, ENSCAFG00845001679, ENSMMUG00000022168, ENSG00000123843
|
| Target Classification |
|
C4BPB siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo725 | Pre-made Human C4BPB/C4BP siRNA oligo Duplex | 725 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24236 | Pre-made Rat C4bpb/C4bp-ps1 siRNA oligo Duplex | 24236 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo693636 | Pre-made Cynomolgus/Rhesus macaque C4BPB siRNA oligo Duplex | 693636 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095148 | Pre-made Cat/Feline C4BPB siRNA oligo Duplex | 101095148 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo609285 | Pre-made Dog/Canine C4BPB siRNA oligo Duplex | 609285 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281652 | Pre-made Bovines/Cattle C4BPB siRNA oligo Duplex | 281652 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051218 | Pre-made Equine/Horse C4BPB siRNA oligo Duplex | 100051218 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
C4BPB antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0162-Ab | Human | Anti-Human C4BPB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP0162-Ab | Rat | Anti-Rat C4BPB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP0162-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque C4BPB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP0162-Ab | Cat/Feline | Anti-Cat/Feline C4BPB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP0162-Ab | Dog/Canine | Anti-Dog/Canine C4BPB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP0162-Ab | Bovines/Cattle | Anti-Bovines/Cattle C4BPB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP0162-Ab | Equine/Horse | Anti-Equine/Horse C4BPB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
C4BPB VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0162-Ag | Human | Human C4BPB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP0162-Ag | Rat | Rat C4BPB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0162-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque C4BPB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP0162-Ag | Cat/Feline | Cat/Feline C4BPB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP0162-Ag | Dog/Canine | Dog/Canine C4BPB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP0162-Ag | Bovines/Cattle | Bovines/Cattle C4BPB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP0162-Ag | Equine/Horse | Equine/Horse C4BPB VLP (virus-like particle) | HEK293 | Products Developing |
