Explore C4 Gamma Chain/C4 Alpha Chain/C4b/C4d/C4A gene products and cross-species
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Target
sublocation: Transmembrane Protein.
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
| Target ID |
GM-MP0160
|
| Target Name |
C4 Gamma Chain/C4 Alpha Chain/C4b/C4d/C4A
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
720
|
| Gene ID |
720 (Homo sapiens)
|
| Target Alternative Names |
Acidic complement C4,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2,C4,C4 Alpha Chain,C4 Gamma Chain,C4A,C4A2,C4A3,C4A4,C4A6,C4AD,C4S,C4b,C4d,CO4,CPAMD2,Complement C4-A,RG
|
| Uniprot Accession |
P0C0L4
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease from KEGG |
Complement and coagulation cascades, Alcoholic liver disease, Pertussis, Staphylococcus aureus infection
|
| Gene Ensembl |
ENSG00000244731
|
C4 Gamma Chain/C4 Alpha Chain/C4b/C4d/C4A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo720 | Pre-made Human C4A/C4/RG siRNA oligo Duplex | 720 | Human | In-vitro grade; in-vivo grade | Detail |
C4 Gamma Chain/C4 Alpha Chain/C4b/C4d/C4A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0160-Ab | Human | Anti-Human C4 Gamma Chain/C4 Alpha Chain/C4b/C4d/C4A monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
C4 Gamma Chain/C4 Alpha Chain/C4b/C4d/C4A VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0160-Ag | Human | Human C4 Gamma Chain/C4 Alpha Chain/C4b/C4d/C4A VLP (virus-like particle) | HEK293 | Products Developing |
