Explore BMPR1B/CDw293 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Target ID |
GM-MP0137
|
Target Name |
BMPR1B/CDw293
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
658
|
Gene ID |
100053554 (Equus caballus), 101082489 (Felis catus), 12167 (Mus musculus), 310914 (Rattus norvegicus) 407128 (Bos taurus), 478484 (Canis lupus familiaris), 658 (Homo sapiens), 705474 (Macaca mulatta)
|
Target Alternative Names |
BMPR1B,Bmpr1b,Alk6,SKR6,ALK-6,Acvrlk6,BMPR-1B,BMPR-IB,CFK-43a,ALK6,BMP15,BMPRIB,AMD3,AMDD,BDA2,BDA1D,CDw293
|
Uniprot Accession |
P36898,O00238
|
Uniprot Entry Name |
|
Protein Sub-location |
Transmembrane Protein
|
Category |
Cytokine Target
|
Disease |
cancer
|
Disease from KEGG |
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Axon guidance, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Fluid shear stress and atherosclerosis
|
Gene Ensembl |
ENSECAG00000012140, ENSMUSG00000052430, ENSBTAG00000002081, ENSCAFG00845021570, ENSG00000138696, ENSMMUG00000006702
|
Target Classification |
Cytokine Receptor, Kinase
|
Pre-made viral vector of BMPR1B/CDw293 cDNA Clones/ORF Plasmid
BMPR1B/CDw293 siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo658 | Pre-made Human BMPR1B/ALK6/AMD3 siRNA oligo Duplex | 658 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo310914 | Pre-made Rat Bmpr1b/CFK-43a siRNA oligo Duplex | 310914 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo12167 | Pre-made Mouse Bmpr1b/Alk6/SKR6 siRNA oligo Duplex | 12167 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo705474 | Pre-made Cynomolgus/Rhesus macaque BMPR1B siRNA oligo Duplex | 705474 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101082489 | Pre-made Cat/Feline BMPR1B siRNA oligo Duplex | 101082489 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo478484 | Pre-made Dog/Canine BMPR1B siRNA oligo Duplex | 478484 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo407128 | Pre-made Bovines/Cattle BMPR1B/ALK6/BMP15 siRNA oligo Duplex | 407128 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100053554 | Pre-made Equine/Horse BMPR1B siRNA oligo Duplex | 100053554 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
BMPR1B/CDw293 antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-MP0137-Ab | Human | Anti-Human BMPR1B/CDw293 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
GM-Tg-rg-MP0137-Ab | Rat | Anti-Rat BMPR1B/CDw293 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
GM-Tg-mg-MP0137-Ab | Mouse | Anti-Mouse BMPR1B/CDw293 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
GM-Tg-cynog-MP0137-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque BMPR1B/CDw293 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
GM-Tg-felg-MP0137-Ab | Cat/Feline | Anti-Cat/Feline BMPR1B/CDw293 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
GM-Tg-cang-MP0137-Ab | Dog/Canine | Anti-Dog/Canine BMPR1B/CDw293 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
GM-Tg-bovg-MP0137-Ab | Bovines/Cattle | Anti-Bovines/Cattle BMPR1B/CDw293 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
GM-Tg-equg-MP0137-Ab | Equine/Horse | Anti-Equine/Horse BMPR1B/CDw293 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
BMPR1B/CDw293 VLP (virus-like particle)
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-MP0137-Ag | Human | Human BMPR1B/CDw293 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-rg-MP0137-Ag | Rat | Rat BMPR1B/CDw293 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-mg-MP0137-Ag | Mouse | Mouse BMPR1B/CDw293 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-cynog-MP0137-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque BMPR1B/CDw293 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-felg-MP0137-Ag | Cat/Feline | Cat/Feline BMPR1B/CDw293 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-cang-MP0137-Ag | Dog/Canine | Dog/Canine BMPR1B/CDw293 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-bovg-MP0137-Ag | Bovines/Cattle | Bovines/Cattle BMPR1B/CDw293 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-equg-MP0137-Ag | Equine/Horse | Equine/Horse BMPR1B/CDw293 VLP (virus-like particle) | HEK293 | Products Developing |