Explore ATP8A2 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the P4 ATPase family of proteins, which are thought to be involved in a process called lipid flipping, whereby phospholipids are translocated inwards from the exoplasmic leaflet to the cytosolic leaflet of the cell membrane, which aids in generating and maintaining asymmetry in membrane lipids. This protein is predicted to contain an E1 E2 ATPase, a haloacid dehalogenase-like hydrolase (HAD) domain, and multiple transmembrane domains. Associations between this protein and cell cycle control protein 50A are important for translocation of phosphatidylserine across membranes. Mutations in this gene have been associated with a syndrome (CAMRQ4) characterized by cerebellar ataxia and cognitive disabilities. In addition, a translocation breakpoint within this gene was observed in an individual with neurological dysfunction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
| Target ID |
GM-MP0119
|
| Target Name |
ATP8A2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
51761
|
| Gene ID |
100687016 (Canis lupus familiaris), 50769 (Mus musculus), 51761 (Homo sapiens), 691889 (Rattus norvegicus)
709311 (Macaca mulatta)
|
| Target Alternative Names |
ATP,ATP8A2,ATPIB,ATPase class I type 8A member 2,Atp8a2,Atpc1b,CAMRQ4,IB,ML-1,P4-ATPase flippase complex alpha subunit ATP8A2,Phospholipid-transporting ATPase IB,agil,wl
|
| Uniprot Accession |
P98200,Q9NTI2
|
| Protein Sub-location |
Transmembrane Protein
|
| Gene Ensembl |
ENSCAFG00845017077, ENSMUSG00000021983, ENSG00000132932, ENSMMUG00000008520
|
ATP8A2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo51761 | Pre-made Human ATP8A2/IB/ATP siRNA oligo Duplex | 51761 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo691889 | Pre-made Rat Atp8a2 siRNA oligo Duplex | 691889 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo50769 | Pre-made Mouse Atp8a2/wl/agil siRNA oligo Duplex | 50769 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo709311 | Pre-made Cynomolgus/Rhesus macaque ATP8A2 siRNA oligo Duplex | 709311 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100687016 | Pre-made Dog/Canine ATP8A2 siRNA oligo Duplex | 100687016 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
ATP8A2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0119-Ab | Human | Anti-Human ATP8A2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP0119-Ab | Rat | Anti-Rat ATP8A2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP0119-Ab | Mouse | Anti-Mouse ATP8A2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP0119-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ATP8A2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP0119-Ab | Dog/Canine | Anti-Dog/Canine ATP8A2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
ATP8A2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0119-Ag | Human | Human ATP8A2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP0119-Ag | Rat | Rat ATP8A2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP0119-Ag | Mouse | Mouse ATP8A2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0119-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ATP8A2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP0119-Ag | Dog/Canine | Dog/Canine ATP8A2 VLP (virus-like particle) | HEK293 | Products Developing |
