Explore PLAP/ALPP gene products and cross-species
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. One of the main sources of this enzyme is the liver, and thus, it's one of several indicators of liver injury in different clinical conditions. In pregnant women, this protein is primarily expressed in placental and endometrial tissue, however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Aug 2020]
| Target ID |
GM-MP0054
|
| Target Name |
PLAP/ALPP
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
250
|
| Gene ID |
250 (Homo sapiens), 712965 (Macaca mulatta)
|
| Target Alternative Names |
ALP,ALPI,ALPP,Alkaline phosphatase,Alkaline phosphatase Regan isozyme,IAP,PALP,PLAP,PLAP-1,Placental alkaline phosphatase 1 (PLAP-1),placental type
|
| Uniprot Accession |
P05187
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease from KEGG |
Metabolic pathways
|
| Gene Ensembl |
ENSG00000163283, ENSMMUG00000016871
|
PLAP/ALPP siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo250 | Pre-made Human ALPP/ALP/IAP siRNA oligo Duplex | 250 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo712965 | Pre-made Cynomolgus/Rhesus macaque ALPP siRNA oligo Duplex | 712965 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
PLAP/ALPP antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0054-Ab | Human | Anti-Human PLAP/ALPP monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP0054-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PLAP/ALPP monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
PLAP/ALPP VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0054-Ag | Human | Human PLAP/ALPP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0054-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PLAP/ALPP VLP (virus-like particle) | HEK293 | Products Developing |
