Explore APAF1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
| Target ID |
GM-IP7960
|
| Target Name |
APAF1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
317
|
| Gene ID |
100052552 (Equus caballus), 11783 (Mus musculus), 317 (Homo sapiens), 482620 (Canis lupus familiaris)
537782 (Bos taurus), 694164 (Macaca mulatta), 768257 (Felis catus), 78963 (Rattus norvegicus)
|
| Target Alternative Names |
6230400I06Rik,APAF-1,APAF1,Apaf-1,Apaf1,Apaf1l,Apoptotic protease-activating factor 1,CED4,fog,mKIAA0413
|
| Uniprot Accession |
O88879,O14727,Q9GL23,Q9EPV5
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Disease |
cancer, Breast Cancer
|
| Gene Ensembl |
ENSECAG00000024703, ENSMUSG00000019979, ENSG00000120868, ENSCAFG00845027232, ENSBTAG00000021661, ENSMMUG00000022404
|
APAF1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo317 | Pre-made Human APAF1/CED4/APAF-1 siRNA oligo Duplex | 317 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo78963 | Pre-made Rat Apaf1 siRNA oligo Duplex | 78963 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11783 | Pre-made Mouse Apaf1/fog/Apaf-1 siRNA oligo Duplex | 11783 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo694164 | Pre-made Cynomolgus/Rhesus macaque APAF1 siRNA oligo Duplex | 694164 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo768257 | Pre-made Cat/Feline APAF1 siRNA oligo Duplex | 768257 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo482620 | Pre-made Dog/Canine APAF1/APAF-1 siRNA oligo Duplex | 482620 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo537782 | Pre-made Bovines/Cattle APAF1 siRNA oligo Duplex | 537782 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052552 | Pre-made Equine/Horse APAF1 siRNA oligo Duplex | 100052552 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
APAF1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP7960-Ab | Human | Anti-Human APAF1 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP7960-Ab | Rat | Anti-Rat APAF1 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP7960-Ab | Mouse | Anti-Mouse APAF1 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP7960-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque APAF1 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP7960-Ab | Cat/Feline | Anti-Cat/Feline APAF1 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP7960-Ab | Dog/Canine | Anti-Dog/Canine APAF1 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP7960-Ab | Bovines/Cattle | Anti-Bovines/Cattle APAF1 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP7960-Ab | Equine/Horse | Anti-Equine/Horse APAF1 monoclonal antibody | mab | | Detail |
APAF1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP7960-Ag | Human | Human APAF1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP7960-Ag | Rat | Rat APAF1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP7960-Ag | Mouse | Mouse APAF1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP7960-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque APAF1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP7960-Ag | Cat/Feline | Cat/Feline APAF1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP7960-Ag | Dog/Canine | Dog/Canine APAF1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP7960-Ag | Bovines/Cattle | Bovines/Cattle APAF1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP7960-Ag | Equine/Horse | Equine/Horse APAF1 recombinant protein | Mammalian cell | Detail |
