Explore ALAS1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
| Target ID |
GM-IP6439
|
| Target Name |
ALAS1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
211
|
| Gene ID |
100060491 (Equus caballus), 101080876 (Felis catus), 11655 (Mus musculus), 211 (Homo sapiens)
476600 (Canis lupus familiaris), 534286 (Bos taurus), 65155 (Rattus norvegicus), 698093 (Macaca mulatta)
|
| Target Alternative Names |
5-aminolevulinate synthase,5-aminolevulinic acid synthase 1,ALA-S,ALAS,ALAS-H,ALAS-N,ALAS1,ALAS3,ALASH,Alas-1,Alas-h,Alas1,Delta-ALA synthase 1,Delta-aminolevulinate synthase 1,MIG4,mitochondrial,non-specific
|
| Uniprot Accession |
Q8VC19,P13196,A6QLI6,P13195
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Disease |
|
| Disease from KEGG |
|
| Gene Ensembl |
ENSECAG00000014533, ENSMUSG00000032786, ENSG00000023330, ENSCAFG00845030692, ENSBTAG00000004118, ENSMMUG00000005596
|
| Target Classification |
|
Pre-made viral vector of ALAS1 cDNA Clones/ORF Plasmid
ALAS1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo211 | Pre-made Human ALAS1/ALAS/MIG4 siRNA oligo Duplex | 211 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo65155 | Pre-made Rat Alas1/ALAS/ALA-S siRNA oligo Duplex | 65155 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11655 | Pre-made Mouse Alas1/ALAS/ALAS-N siRNA oligo Duplex | 11655 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo698093 | Pre-made Cynomolgus/Rhesus macaque ALAS1 siRNA oligo Duplex | 698093 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101080876 | Pre-made Cat/Feline ALAS1 siRNA oligo Duplex | 101080876 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo476600 | Pre-made Dog/Canine ALAS1 siRNA oligo Duplex | 476600 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo534286 | Pre-made Bovines/Cattle ALAS1/ALAS-H siRNA oligo Duplex | 534286 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060491 | Pre-made Equine/Horse ALAS1 siRNA oligo Duplex | 100060491 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ALAS1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP6439-Ab | Human | Anti-Human ALAS1 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP6439-Ab | Rat | Anti-Rat ALAS1 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP6439-Ab | Mouse | Anti-Mouse ALAS1 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP6439-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ALAS1 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP6439-Ab | Cat/Feline | Anti-Cat/Feline ALAS1 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP6439-Ab | Dog/Canine | Anti-Dog/Canine ALAS1 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP6439-Ab | Bovines/Cattle | Anti-Bovines/Cattle ALAS1 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP6439-Ab | Equine/Horse | Anti-Equine/Horse ALAS1 monoclonal antibody | mab | | Detail |
ALAS1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP6439-Ag | Human | Human ALAS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP6439-Ag | Rat | Rat ALAS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP6439-Ag | Mouse | Mouse ALAS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP6439-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ALAS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP6439-Ag | Cat/Feline | Cat/Feline ALAS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP6439-Ag | Dog/Canine | Dog/Canine ALAS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP6439-Ag | Bovines/Cattle | Bovines/Cattle ALAS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP6439-Ag | Equine/Horse | Equine/Horse ALAS1 recombinant protein | Mammalian cell | Detail |
