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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
| Target ID |
GM-IP3358
|
| Target Name |
PSME3
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
10197
|
| Gene ID |
100065788 (Equus caballus), 100336105 (Bos taurus), 101101426 (Felis catus), 10197 (Homo sapiens) 19192 (Mus musculus), 287716 (Rattus norvegicus), 480512 (Canis lupus familiaris), 711900 (Macaca mulatta)
|
| Target Alternative Names |
11S regulator complex subunit gamma (REG-gamma),Ab2-371,Activator of multicatalytic protease subunit 3,HEL-S-283,Ki,Ki nuclear autoantigen,PA28-gamma,PA28G,PA28gamma,PA28gamma),PSME3,Proteasome activator 28 subunit gamma (PA28g,Proteasome activator complex subunit 3,Psme3,REG-GAMMA,REGgamma,pa28g
|
| Uniprot Accession |
P61289,P61290
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Gene Ensembl |
ENSECAG00000011604, ENSBTAG00000019918, ENSG00000131467, ENSMUSG00000078652, ENSCAFG00845007222, ENSMMUG00000012685
|
Pre-made viral vector of PSME3 cDNA Clones/ORF Plasmid
PSME3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10197 | Pre-made Human PSME3/Ki/PA28G siRNA oligo Duplex | 10197 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo287716 | Pre-made Rat Psme3/Ab2-371 siRNA oligo Duplex | 287716 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19192 | Pre-made Mouse Psme3/Ki/pa28g siRNA oligo Duplex | 19192 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo711900 | Pre-made Cynomolgus/Rhesus macaque PSME3 siRNA oligo Duplex | 711900 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101101426 | Pre-made Cat/Feline PSME3 siRNA oligo Duplex | 101101426 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo480512 | Pre-made Dog/Canine PSME3 siRNA oligo Duplex | 480512 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100336105 | Pre-made Bovines/Cattle PSME3 siRNA oligo Duplex | 100336105 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100065788 | Pre-made Equine/Horse PSME3 siRNA oligo Duplex | 100065788 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PSME3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP3358-Ab | Human | Anti-Human PSME3 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP3358-Ab | Rat | Anti-Rat PSME3 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP3358-Ab | Mouse | Anti-Mouse PSME3 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP3358-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PSME3 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP3358-Ab | Cat/Feline | Anti-Cat/Feline PSME3 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP3358-Ab | Dog/Canine | Anti-Dog/Canine PSME3 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP3358-Ab | Bovines/Cattle | Anti-Bovines/Cattle PSME3 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP3358-Ab | Equine/Horse | Anti-Equine/Horse PSME3 monoclonal antibody | mab | | Detail |
PSME3 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP3358-Ag | Human | Human PSME3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP3358-Ag | Rat | Rat PSME3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP3358-Ag | Mouse | Mouse PSME3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP3358-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PSME3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP3358-Ag | Cat/Feline | Cat/Feline PSME3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP3358-Ag | Dog/Canine | Dog/Canine PSME3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP3358-Ag | Bovines/Cattle | Bovines/Cattle PSME3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP3358-Ag | Equine/Horse | Equine/Horse PSME3 recombinant protein | Mammalian cell | Detail |