UGT1A9 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein
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Target
sublocation: Introcelluar Protein.
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq, Jul 2008]
| Target ID | GM-IP2231 |
| Target Name | UGT1A9 |
|
Gene Group ldentifer （Target Gene ID in Homo species) |
54600 |
| Target Alternative Names | HLUGP4,LUGP4,UDP-glucuronosyltransferase 1-9 (UDPGT 1-9,UDP-glucuronosyltransferase 1-I (UGT-1I,UDP-glucuronosyltransferase 1A9,UDPGT,UDPGT 1-9,UGT-1I,UGT1*9,UGT1-09,UGT1-9,UGT1.9,UGT1.9),UGT1A9,UGT1A9S,UGT1AI,UGT1I,UGT1I),lugP4 |
| Protein Sub-location | Introcelluar Protein |
| Disease from KEGG | Metabolic pathways, Steroid hormone biosynthesis, Pentose and glucuronate interconversions, Bile secretion, Chemical carcinogenesis - DNA adducts, Chemical carcinogenesis - receptor activation, Ascorbate and aldarate metabolism, Retinol metabolism, Porphyrin metabolism, Drug metabolism - cytochrome P450 |