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Target
sublocation: Introcelluar Protein.
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. [provided by RefSeq, Jul 2008]
| Target ID |
GM-IP2230
|
| Target Name |
UGT1A8
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
54576
|
| Gene ID |
54576 (Homo sapiens)
|
| Target Alternative Names |
GNT1,UDP-glucuronosyltransferase 1-8 (UDPGT 1-8,UDP-glucuronosyltransferase 1-H (UGT-1H,UDP-glucuronosyltransferase 1A8,UDPGT,UDPGT 1-1,UDPGT 1-8,UGT-1A,UGT-1H,UGT1,UGT1*8,UGT1-01,UGT1-08,UGT1.1,UGT1.8,UGT1.8),UGT1A,UGT1A1,UGT1A8,UGT1A8S,UGT1H,UGT1H),hUG-BR1
|
| Uniprot Accession |
Q9HAW9
|
| Protein Sub-location |
Introcelluar Protein
|
| Disease from KEGG |
Metabolic pathways, Steroid hormone biosynthesis, Pentose and glucuronate interconversions, Bile secretion, Chemical carcinogenesis - DNA adducts, Chemical carcinogenesis - receptor activation, Ascorbate and aldarate metabolism, Retinol metabolism, Porphyrin metabolism, Drug metabolism - cytochrome P450
|
| Gene Ensembl |
ENSG00000242366
|
Pre-made viral vector of UGT1A8 cDNA Clones/ORF Plasmid
UGT1A8 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo54576 | Pre-made Human UGT1A8/GNT1/UGT1 siRNA oligo Duplex | 54576 | Human | In-vitro grade; in-vivo grade | Detail |
UGT1A8 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP2230-Ab | Human | Anti-Human UGT1A8 monoclonal antibody | mab | | Detail |
UGT1A8 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP2230-Ag | Human | Human UGT1A8 recombinant protein | Mammalian cell | Detail |
