Explore CCM2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
| Target ID |
GM-IP12699
|
| Target Name |
CCM2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
83605
|
| Gene ID |
100065340 (Equus caballus), 100856167 (Canis lupus familiaris), 101100375 (Felis catus), 216527 (Mus musculus)
305505 (Rattus norvegicus), 506450 (Bos taurus), 705037 (Macaca mulatta), 83605 (Homo sapiens)
|
| Target Alternative Names |
C7orf22,CCM2,Ccm2,Cerebral cavernous malformations 2 protein,Malcavernin,OSM,PP10187
|
| Uniprot Accession |
Q8K2Y9,Q9BSQ5
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000017258, ENSCAFG00845011022, ENSMUSG00000000378, ENSBTAG00000008090, ENSMMUG00000001799, ENSG00000136280
|
Pre-made viral vector of CCM2 cDNA Clones/ORF Plasmid
CCM2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo83605 | Pre-made Human CCM2/OSM/C7orf22 siRNA oligo Duplex | 83605 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo305505 | Pre-made Rat Ccm2 siRNA oligo Duplex | 305505 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo216527 | Pre-made Mouse Ccm2 siRNA oligo Duplex | 216527 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo705037 | Pre-made Cynomolgus/Rhesus macaque CCM2 siRNA oligo Duplex | 705037 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100375 | Pre-made Cat/Feline CCM2 siRNA oligo Duplex | 101100375 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100856167 | Pre-made Dog/Canine CCM2 siRNA oligo Duplex | 100856167 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo506450 | Pre-made Bovines/Cattle CCM2 siRNA oligo Duplex | 506450 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100065340 | Pre-made Equine/Horse CCM2 siRNA oligo Duplex | 100065340 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CCM2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP12699-Ab | Human | Anti-Human CCM2 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP12699-Ab | Rat | Anti-Rat CCM2 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP12699-Ab | Mouse | Anti-Mouse CCM2 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP12699-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CCM2 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP12699-Ab | Cat/Feline | Anti-Cat/Feline CCM2 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP12699-Ab | Dog/Canine | Anti-Dog/Canine CCM2 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP12699-Ab | Bovines/Cattle | Anti-Bovines/Cattle CCM2 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP12699-Ab | Equine/Horse | Anti-Equine/Horse CCM2 monoclonal antibody | mab | | Detail |
CCM2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP12699-Ag | Human | Human CCM2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP12699-Ag | Rat | Rat CCM2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP12699-Ag | Mouse | Mouse CCM2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP12699-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CCM2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP12699-Ag | Cat/Feline | Cat/Feline CCM2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP12699-Ag | Dog/Canine | Dog/Canine CCM2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP12699-Ag | Bovines/Cattle | Bovines/Cattle CCM2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP12699-Ag | Equine/Horse | Equine/Horse CCM2 recombinant protein | Mammalian cell | Detail |
