TPMT Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore TPMT gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Introcelluar Protein.
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]

Target ID	GM-IP11719
Target Name	TPMT
Gene Group ldentifer （Target Gene ID in Homo species)	7172
Gene ID	100034066 (Equus caballus), 22017 (Mus musculus), 403536 (Canis lupus familiaris), 493759 (Felis catus) 511644 (Bos taurus), 690050 (Rattus norvegicus), 704564 (Macaca mulatta), 7172 (Homo sapiens)
Target Alternative Names	TPMT,TPMTD,Thiopurine S-methyltransferase,Thiopurine methyltransferase,Tpmt
Uniprot Accession	Q3BCR6,O55060,Q8HX86,Q6EIC1,Q17QQ2,Q9Z0T0,P51580
Protein Sub-location	Introcelluar Protein
Category	Life Science Target
Disease	cancer, Sensitivity to chemotherapy
Gene Ensembl	ENSECAG00000013653, ENSMUSG00000021376, ENSCAFG00845028681, ENSBTAG00000019300, ENSMMUG00000016627, ENSG00000137364

Pre-made viral vector of TPMT cDNA Clones/ORF Plasmid

Cat No.	Product Name	NMID	GeneID	Species	Type	Marker	Fusion Tag	Promoter	Detail
pGMLP002969	Human TPMT/TPMTD Lentivirus plasmid	NM_000367	7172	Human	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMLP002969	Human TPMT/TPMTD Lentivirus particle	NM_000367	7172	Human	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMLPm000986	Mouse Tpmt/AW106912 Lentivirus plasmid	NM_016785	22017	Mouse	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMLPm000986	Mouse Tpmt/AW106912 Lentivirus particle	NM_016785	22017	Mouse	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail

TPMT siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.	Product Name	GeneID	Species	Grade	Detail
pGMoligo7172	Pre-made Human TPMT/TPMTD siRNA oligo Duplex	7172	Human	In-vitro grade; in-vivo grade	Detail
pGMoligo690050	Pre-made Rat Tpmt siRNA oligo Duplex	690050	Rat	In-vitro grade; in-vivo grade	Detail
pGMoligo22017	Pre-made Mouse Tpmt siRNA oligo Duplex	22017	Mouse	In-vitro grade; in-vivo grade	Detail
pGMoligo704564	Pre-made Cynomolgus/Rhesus macaque TPMT siRNA oligo Duplex	704564	Cynomolgus/Rhesus macaque	In-vitro grade; in-vivo grade	Detail
pGMoligo493759	Pre-made Cat/Feline TPMT siRNA oligo Duplex	493759	Cat/Feline	In-vitro grade; in-vivo grade	Detail
pGMoligo403536	Pre-made Dog/Canine TPMT siRNA oligo Duplex	403536	Dog/Canine	In-vitro grade; in-vivo grade	Detail
pGMoligo511644	Pre-made Bovines/Cattle TPMT siRNA oligo Duplex	511644	Bovines/Cattle	In-vitro grade; in-vivo grade	Detail
pGMoligo100034066	Pre-made Equine/Horse TPMT siRNA oligo Duplex	100034066	Equine/Horse	In-vitro grade; in-vivo grade	Detail

TPMT antibody/GMab

Cat No.	Species	Antibody Name	Format	Detail
GM-Tg-hg-IP11719-Ab	Human	Anti-Human TPMT monoclonal antibody	mab	Detail
GM-Tg-rg-IP11719-Ab	Rat	Anti-Rat TPMT monoclonal antibody	mab	Detail
GM-Tg-mg-IP11719-Ab	Mouse	Anti-Mouse TPMT monoclonal antibody	mab	Detail
GM-Tg-cynog-IP11719-Ab	Cynomolgus/Rhesus macaque	Anti-Cynomolgus/Rhesus macaque TPMT monoclonal antibody	mab	Detail
GM-Tg-felg-IP11719-Ab	Cat/Feline	Anti-Cat/Feline TPMT monoclonal antibody	mab	Detail
GM-Tg-cang-IP11719-Ab	Dog/Canine	Anti-Dog/Canine TPMT monoclonal antibody	mab	Detail
GM-Tg-bovg-IP11719-Ab	Bovines/Cattle	Anti-Bovines/Cattle TPMT monoclonal antibody	mab	Detail
GM-Tg-equg-IP11719-Ab	Equine/Horse	Anti-Equine/Horse TPMT monoclonal antibody	mab	Detail

TPMT recombinant protein

Cat No.	Species	Antigen Name	Expression Platform	Detail
GM-Tg-hg-IP11719-Ag	Human	Human TPMT recombinant protein	Mammalian cell	Detail
GM-Tg-rg-IP11719-Ag	Rat	Rat TPMT recombinant protein	Mammalian cell	Detail
GM-Tg-mg-IP11719-Ag	Mouse	Mouse TPMT recombinant protein	Mammalian cell	Detail
GM-Tg-cynog-IP11719-Ag	Cynomolgus/Rhesus macaque	Cynomolgus/Rhesus macaque TPMT recombinant protein	Mammalian cell	Detail
GM-Tg-felg-IP11719-Ag	Cat/Feline	Cat/Feline TPMT recombinant protein	Mammalian cell	Detail
GM-Tg-cang-IP11719-Ag	Dog/Canine	Dog/Canine TPMT recombinant protein	Mammalian cell	Detail
GM-Tg-bovg-IP11719-Ag	Bovines/Cattle	Bovines/Cattle TPMT recombinant protein	Mammalian cell	Detail
GM-Tg-equg-IP11719-Ag	Equine/Horse	Equine/Horse TPMT recombinant protein	Mammalian cell	Detail