Explore SHMT1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
| Target ID |
GM-IP11299
|
| Target Name |
SHMT1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
6470
|
| Gene ID |
100051522 (Equus caballus), 101086266 (Felis catus), 20425 (Mus musculus), 287379 (Rattus norvegicus)
489536 (Canis lupus familiaris), 509002 (Bos taurus), 6470 (Homo sapiens), 701186 (Macaca mulatta)
|
| Target Alternative Names |
CSHMT,Glycine hydroxymethyltransferase,LRRGT00032,SHMT,SHMT1,Serine hydroxymethyltransferase,Serine methylase,Shmt,Shmt1,cytosolic,mShmt,mshmt,mshmt1,mshmt2
|
| Uniprot Accession |
P50431,Q5E9P9,P34896
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000015690, ENSMUSG00000020534, ENSCAFG00845020125, ENSBTAG00000017094, ENSG00000176974, ENSMMUG00000013535
|
Pre-made viral vector of SHMT1 cDNA Clones/ORF Plasmid
SHMT1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6470 | Pre-made Human SHMT1/SHMT/CSHMT siRNA oligo Duplex | 6470 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo287379 | Pre-made Rat Shmt1/Shmt/mShmt siRNA oligo Duplex | 287379 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20425 | Pre-made Mouse Shmt1/Shmt/mshmt siRNA oligo Duplex | 20425 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo701186 | Pre-made Cynomolgus/Rhesus macaque SHMT1 siRNA oligo Duplex | 701186 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086266 | Pre-made Cat/Feline SHMT1 siRNA oligo Duplex | 101086266 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489536 | Pre-made Dog/Canine SHMT1 siRNA oligo Duplex | 489536 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo509002 | Pre-made Bovines/Cattle SHMT1 siRNA oligo Duplex | 509002 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051522 | Pre-made Equine/Horse SHMT1 siRNA oligo Duplex | 100051522 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SHMT1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP11299-Ab | Human | Anti-Human SHMT1 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP11299-Ab | Rat | Anti-Rat SHMT1 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP11299-Ab | Mouse | Anti-Mouse SHMT1 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP11299-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SHMT1 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP11299-Ab | Cat/Feline | Anti-Cat/Feline SHMT1 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP11299-Ab | Dog/Canine | Anti-Dog/Canine SHMT1 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP11299-Ab | Bovines/Cattle | Anti-Bovines/Cattle SHMT1 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP11299-Ab | Equine/Horse | Anti-Equine/Horse SHMT1 monoclonal antibody | mab | | Detail |
SHMT1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP11299-Ag | Human | Human SHMT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP11299-Ag | Rat | Rat SHMT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP11299-Ag | Mouse | Mouse SHMT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP11299-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SHMT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP11299-Ag | Cat/Feline | Cat/Feline SHMT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP11299-Ag | Dog/Canine | Dog/Canine SHMT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP11299-Ag | Bovines/Cattle | Bovines/Cattle SHMT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP11299-Ag | Equine/Horse | Equine/Horse SHMT1 recombinant protein | Mammalian cell | Detail |
