LARGE/LARGE1 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

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Target sublocation: Introcelluar Protein.
This gene encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. The protein encoded by this gene is the glycotransferase that adds the final xylose and glucuronic acid to alpha-dystroglycan and thereby allows alpha-dystroglycan to bind ligands including laminin 211 and neurexin. Mutations in this gene cause several forms of congenital muscular dystrophy characterized by cognitive disability and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2018]

LARGE/LARGE1 siRNA/miRNA/oligo for RNA interfence (RNAi)

LARGE/LARGE1 antibody/GMab

LARGE/LARGE1 recombinant protein