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Target
sublocation: Introcelluar Protein.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008]
| Target ID |
GM-IP10567
|
| Target Name |
PSME2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5721
|
| Gene ID |
100051729 (Equus caballus), 101100476 (Felis catus), 19188 (Mus musculus), 29614 (Rattus norvegicus) 480258 (Canis lupus familiaris), 509857 (Bos taurus), 5721 (Homo sapiens), 715288 (Macaca mulatta)
|
| Target Alternative Names |
11S regulator complex subunit beta (REG-beta),Activator of multicatalytic protease subunit 2,PA28B,PA28b,PA28beta,PA28beta),PSME2,Proteasome activator 28 subunit beta (PA28b,Proteasome activator complex subunit 2,Psme2,REGbeta
|
| Uniprot Accession |
P97372,Q63798,Q5E9G3,Q9UL46
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Gene Ensembl |
ENSECAG00000017910, ENSMUSG00000079197, ENSCAFG00845004671, ENSBTAG00000005814, ENSG00000100911, ENSMMUG00000012473
|
Pre-made viral vector of PSME2 cDNA Clones/ORF Plasmid
PSME2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5721 | Pre-made Human PSME2/PA28B/REGbeta siRNA oligo Duplex | 5721 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29614 | Pre-made Rat Psme2 siRNA oligo Duplex | 29614 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19188 | Pre-made Mouse Psme2/PA28b siRNA oligo Duplex | 19188 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo715288 | Pre-made Cynomolgus/Rhesus macaque PSME2 siRNA oligo Duplex | 715288 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100476 | Pre-made Cat/Feline PSME2 siRNA oligo Duplex | 101100476 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo480258 | Pre-made Dog/Canine PSME2 siRNA oligo Duplex | 480258 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo509857 | Pre-made Bovines/Cattle PSME2 siRNA oligo Duplex | 509857 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051729 | Pre-made Equine/Horse PSME2 siRNA oligo Duplex | 100051729 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PSME2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP10567-Ab | Human | Anti-Human PSME2 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP10567-Ab | Rat | Anti-Rat PSME2 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP10567-Ab | Mouse | Anti-Mouse PSME2 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP10567-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PSME2 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP10567-Ab | Cat/Feline | Anti-Cat/Feline PSME2 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP10567-Ab | Dog/Canine | Anti-Dog/Canine PSME2 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP10567-Ab | Bovines/Cattle | Anti-Bovines/Cattle PSME2 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP10567-Ab | Equine/Horse | Anti-Equine/Horse PSME2 monoclonal antibody | mab | | Detail |
PSME2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP10567-Ag | Human | Human PSME2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP10567-Ag | Rat | Rat PSME2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP10567-Ag | Mouse | Mouse PSME2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP10567-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PSME2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP10567-Ag | Cat/Feline | Cat/Feline PSME2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP10567-Ag | Dog/Canine | Dog/Canine PSME2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP10567-Ag | Bovines/Cattle | Bovines/Cattle PSME2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP10567-Ag | Equine/Horse | Equine/Horse PSME2 recombinant protein | Mammalian cell | Detail |