GCLC Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore GCLC gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Introcelluar Protein.
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]

Target ID	GM-IP0890
Target Name	GCLC
Gene Group ldentifer （Target Gene ID in Homo species)	2729
Gene ID	100056731 (Equus caballus), 101096568 (Felis catus), 14629 (Mus musculus), 25283 (Rattus norvegicus) 2729 (Homo sapiens), 512468 (Bos taurus), 609822 (Canis lupus familiaris), 710508 (Macaca mulatta)
Target Alternative Names	CNSHA7,D9Wsu168e,GCL,GCLC,GCS,GCS heavy chain,GLCL,GLCL-H,GLCLC,Gamma-ECS,Gamma-glutamylcysteine synthetase,Gclc,Ggcs-hs,Glclc,Glutamate--cysteine ligase catalytic subunit
Uniprot Accession	P97494,P19468,P48506
Protein Sub-location	Introcelluar Protein
Disease from KEGG	Metabolic pathways, Ferroptosis
Gene Ensembl	ENSECAG00000017346, ENSMUSG00000032350, ENSG00000001084, ENSBTAG00000015571, ENSCAFG00845010300, ENSMMUG00000008684

Pre-made viral vector of GCLC cDNA Clones/ORF Plasmid

Cat No.	Product Name	NMID	GeneID	Species	Type	Marker	Fusion Tag	Promoter	Detail
pGMLP002985	Human GCLC/GCL/GCS Lentivirus plasmid	NM_001498	2729	Human	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMPC004862	Human GCLC/GCL/GCS Mammalian (Non-Viral Vector) plasmid	NM_001498.4	2729	Human	Mammalian (Non-Viral Vector) plasmid	EGFP	3xflag (C-Terminal)	EF1	Detail
vGMLP002985	Human GCLC/GCL/GCS Lentivirus particle	NM_001498	2729	Human	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMLV001715	Mouse Gclc/D9Wsu168e/Ggcs-hs Lentivirus plasmid	NM_010295.2	14629	Mouse	Lentivirus plasmid	Null	3xflag (C-Terminal)	CMV	Detail
pGMLPm003411	Mouse Gclc/D9Wsu168e/Ggcs-hs Lentivirus plasmid	NM_010295.2	14629	Mouse	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMLV001715	Mouse Gclc/D9Wsu168e/Ggcs-hs Lentivirus particle	NM_010295.2	14629	Mouse	Lentivirus particle	Null	3xflag (C-Terminal)	CMV	Detail
vGMLPm003411	Mouse Gclc/D9Wsu168e/Ggcs-hs Lentivirus particle	NM_010295.2	14629	Mouse	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail

GCLC siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.	Product Name	GeneID	Species	Grade	Detail
pGMoligo2729	Pre-made Human GCLC/GCL/GCS siRNA oligo Duplex	2729	Human	In-vitro grade; in-vivo grade	Detail
pGMoligo25283	Pre-made Rat Gclc/Glclc siRNA oligo Duplex	25283	Rat	In-vitro grade; in-vivo grade	Detail
pGMoligo14629	Pre-made Mouse Gclc/Glclc/GLCL-H siRNA oligo Duplex	14629	Mouse	In-vitro grade; in-vivo grade	Detail
pGMoligo710508	Pre-made Cynomolgus/Rhesus macaque GCLC siRNA oligo Duplex	710508	Cynomolgus/Rhesus macaque	In-vitro grade; in-vivo grade	Detail
pGMoligo101096568	Pre-made Cat/Feline GCLC siRNA oligo Duplex	101096568	Cat/Feline	In-vitro grade; in-vivo grade	Detail
pGMoligo609822	Pre-made Dog/Canine GCLC siRNA oligo Duplex	609822	Dog/Canine	In-vitro grade; in-vivo grade	Detail
pGMoligo512468	Pre-made Bovines/Cattle GCLC siRNA oligo Duplex	512468	Bovines/Cattle	In-vitro grade; in-vivo grade	Detail
pGMoligo100056731	Pre-made Equine/Horse GCLC siRNA oligo Duplex	100056731	Equine/Horse	In-vitro grade; in-vivo grade	Detail

GCLC antibody/GMab

Cat No.	Species	Antibody Name	Format	Detail
GM-Tg-hg-IP0890-Ab	Human	Anti-Human GCLC monoclonal antibody	mab	Detail
GM-Tg-rg-IP0890-Ab	Rat	Anti-Rat GCLC monoclonal antibody	mab	Detail
GM-Tg-mg-IP0890-Ab	Mouse	Anti-Mouse GCLC monoclonal antibody	mab	Detail
GM-Tg-cynog-IP0890-Ab	Cynomolgus/Rhesus macaque	Anti-Cynomolgus/Rhesus macaque GCLC monoclonal antibody	mab	Detail
GM-Tg-felg-IP0890-Ab	Cat/Feline	Anti-Cat/Feline GCLC monoclonal antibody	mab	Detail
GM-Tg-cang-IP0890-Ab	Dog/Canine	Anti-Dog/Canine GCLC monoclonal antibody	mab	Detail
GM-Tg-bovg-IP0890-Ab	Bovines/Cattle	Anti-Bovines/Cattle GCLC monoclonal antibody	mab	Detail
GM-Tg-equg-IP0890-Ab	Equine/Horse	Anti-Equine/Horse GCLC monoclonal antibody	mab	Detail

GCLC recombinant protein

Cat No.	Species	Antigen Name	Expression Platform	Detail
GM-Tg-hg-IP0890-Ag	Human	Human GCLC recombinant protein	Mammalian cell	Detail
GM-Tg-rg-IP0890-Ag	Rat	Rat GCLC recombinant protein	Mammalian cell	Detail
GM-Tg-mg-IP0890-Ag	Mouse	Mouse GCLC recombinant protein	Mammalian cell	Detail
GM-Tg-cynog-IP0890-Ag	Cynomolgus/Rhesus macaque	Cynomolgus/Rhesus macaque GCLC recombinant protein	Mammalian cell	Detail
GM-Tg-felg-IP0890-Ag	Cat/Feline	Cat/Feline GCLC recombinant protein	Mammalian cell	Detail
GM-Tg-cang-IP0890-Ag	Dog/Canine	Dog/Canine GCLC recombinant protein	Mammalian cell	Detail
GM-Tg-bovg-IP0890-Ag	Bovines/Cattle	Bovines/Cattle GCLC recombinant protein	Mammalian cell	Detail
GM-Tg-equg-IP0890-Ag	Equine/Horse	Equine/Horse GCLC recombinant protein	Mammalian cell	Detail